SMARCAD1 and SLC39A8

		SMARCAD1	SLC39A8
Description		SNF2 related chromatin remodeling ATPase with DExD box 1	solute carrier family 39 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Nuclear Replication Fork	Lysosome Lysosomal Membrane Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Organelle Membrane
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	Zinc Ion Transmembrane Transporter Activity Symporter Activity Metal Ion Transmembrane Transporter Activity Monoatomic Cation:bicarbonate Symporter Activity Zinc:bicarbonate Symporter Activity
	Biological Process	Regulation Of DNA Recombination DNA Double-strand Break Processing DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Positive Regulation Of Transcription By RNA Polymerase II Chromosome Separation	DNA-templated Transcription Regulation Of DNA-templated Transcription Protein N-linked Glycosylation Arginine Metabolic Process Monoatomic Ion Transport Cobalt Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Mercury Ion Transport Bicarbonate Transport Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Manganese Ion Homeostasis Extracellular Matrix Organization Regulation Of Membrane Potential Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Inflammatory Response Transmembrane Transport Leukocyte Adhesion To Arterial Endothelial Cell Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Iron Ion Import Across Plasma Membrane Cellular Detoxification Of Cadmium Ion Cartilage Homeostasis Mitochondrial Manganese Ion Transmembrane Transport
Pathways			Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 28869591 30598549) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604732 28604728 23666239) Type 2 diabetes ( 30297969)	A body shape index ( 34021172) Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Allergic disease (asthma, hay fever or eczema) ( 29679657) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anterior thalamic nuclei volume ( 34006833) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Blood pressure ( 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 25673413 26961502 28448500 28552196 29273807 29381148) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 26604143 33045005) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 21909115 27618452 27841878 28739976 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil percentage of white cells ( 32888494) Erythrocyte cadmium concentration in never smokers ( 27005419) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol ( 20686565 24097068 25961943 30275531) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hypertension ( 21909115 31879980) Inflammatory bowel disease ( 28067908) Initial pursuit acceleration ( 29064472) Intelligence (MTAG) ( 29326435) Lateral thalamic nuclei volume ( 34006833) LDL cholesterol levels ( 32203549) Left-handedness ( 32989287) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Manganese levels ( 26025379) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Multisite chronic pain ( 31194737 33830993) NT-proBNP levels in acute coronary syndrome ( 26908625) Obese vs. thin ( 30677029) Parkinson's disease ( 32201043) Platelet distribution width ( 27863252 32888494) Problematic alcohol use ( 32451486) Red blood cell count ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656) Serum total protein levels ( 29403010) Shoulder impingement or rotator cuff tear ( 33482370) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 21909115 27618447 27618452 27841878 28739976 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731 32203549) Voxel-wise structural brain imaging measurements ( 30649180) vWF levels ( 30586737) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: CBS GTF3C3 PCNA SLC39A8 SUMO1 SUMO2 TOPBP1 TRIM28	6 interacting genes: ADH6 BMPR1B CXXC4 PTGER4 SMARCAD1 STPG2
Entrez ID		56916	64116
HPRD ID		11586	12286
Ensembl ID		ENSG00000163104	ENSG00000138821
Uniprot IDs		Q9H4L7	Q9C0K1
PDB IDs		6H3A 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Nucleic Acid Metabolic Process Protein Sumoylation DNA Metabolic Process Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process PML Body Protein Tag Activity Macromolecule Metabolic Process SUMO Transferase Activity DNA Repair Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Response To Cadmium Ion DNA Damage Response Male Germ Cell Nucleus Cellular Response To Stress PCNA Complex Replisome Regulation Of Protein Import Into Nucleus Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Nuclear Body Enzyme Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Krueppel-associated Box Domain Binding Broken Chromosome Clustering Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Carbon Monoxide Binding Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Localization To Nuclear Pore Ubiquitin-like Protein Ligase Activity Cellular Detoxification Of Cadmium Ion Cysteine Biosynthetic Process L-serine Catabolic Process Transsulfuration Homocysteine Catabolic Process	Bone Development Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Ovarian Cumulus Expansion Prostaglandin E Receptor Activity Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Nucleosome Array Spacer Activity Zygotic Specification Of Dorsal/ventral Axis
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