EXOSC5 and YTHDF3

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EXOSC5	YTHDF3
Description		exosome component 5	YTH N6-methyladenosine RNA binding protein F3
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	3'-5'-RNA Exonuclease Activity DNA Binding RNA Binding RNA Exonuclease Activity Protein Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing	Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Organelle Assembly Regulation Of Trophoblast Cell Migration
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Myocardial infarction ( 26708285) Schizophrenia ( 33169155) Smoking behaviour (cigarettes smoked per day) ( 30679032) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		86 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 CEP55 CPSF7 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HAMP HOXC4 IKZF3 KCTD13 KIAA1217 KMT2A KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PAF1 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PRODH2 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 YTHDF3 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	19 interacting genes: ALG13 ANKHD1 CPSF7 CTTN DMRTB1 EXOSC5 FAF1 GGH LARP4 MAT2B NMD3 PRRC2B QKI RBFOX2 RBM22 RPS21 SF1 SNRPA ZDHHC17
Entrez ID		56915	253943
HPRD ID		16222	08106
Ensembl ID		ENSG00000077348	ENSG00000185728
Uniprot IDs		Q9NQT4	A0A024R7W5 A0A087WY31 B4DPX9 Q7Z739 Q8NA80
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	6ZOT 8BS5 8BS6
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay Nuclear MRNA Surveillance Nuclear RNA Surveillance RNA Surveillance RRNA Processing SnRNA Metabolic Process RRNA Metabolic Process RNA 3'-end Processing RNA Processing SnRNA 3'-end Processing CUT Catabolic Process RNA Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Processing MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process RNA Metabolic Process Sno(s)RNA Metabolic Process Exoribonuclease Complex TRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Structural Constituent Of Skin Epidermis Cytosol Intermediate Filament Organization Nucleic Acid Metabolic Process RNA Binding Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination	RNA Binding Nucleic Acid Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome MRNA Binding Cytosolic Small Ribosomal Subunit Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleic Acid Metabolic Process Spliceosomal Complex Gamma-glutamyl-peptidase Activity Regulation Of RNA Splicing Internal N(7)-methylguanine-containing RNA Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Methionine Adenosyltransferase Regulator Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Macromolecule Metabolic Process
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