SPIRE1 and CEP192

		SPIRE1	CEP192
Description		spire type actin nucleation factor 1	centrosomal protein 192
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cleavage Furrow Perinuclear Region Of Cytoplasm	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Procentriole Procentriole Replication Complex
	Molecular Function	Actin Binding Protein Binding Microtubule Binding	Protein Binding Phosphatase Binding
	Biological Process	Immune System Process Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Innate Immune Response Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Mitochondrial Fission Positive Regulation Of Double-strand Break Repair	Centrosome Cycle Centriole Replication Response To Bacterium Centrosome Duplication Protein Localization To Centrosome Centrosome-templated Microtubule Nucleation Mitotic Spindle Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Red blood cell count ( 32888494)	Appendicular lean mass ( 33097823) General cognitive ability ( 29844566)
Interacting Genes		4 interacting genes: BBS4 CEP192 ETS1 PLEKHA5	7 interacting genes: CIP2A CTAGE1 LINC00839 PPP1CA SHBG SPIRE1 UBC
Entrez ID		56907	55125
HPRD ID		11600	10855
Ensembl ID		ENSG00000134278	ENSG00000101639
Uniprot IDs		J3KNG6 Q08AE8	Q8TEP8
PDB IDs		2YLE 2YLF 3R7G 3RBW	4N7Z 6FVI 6W3J 7PTB 8GUW 8PR7
Enriched GO Terms of Interacting Partners?		Pericentriolar Material Protein Localization To Centrosome Protein Localization To Cytoskeleton Centrosome Cycle Microtubule Organizing Center Organization Centrosome-templated Microtubule Nucleation Centriole RNA Polymerase II-specific DNA-binding Transcription Factor Binding Procentriole Sensory Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Nucleation By Microtubule Organizing Center Protein Localization To Photoreceptor Outer Segment Procentriole Replication Complex BBSome PML Body Organization Microtubule Anchoring At Centrosome Protein Localization To Non-motile Cilium Retinal Rod Cell Development Negative Regulation Of Appetite Fat Pad Development Erythrocyte Homeostasis Leptin-mediated Signaling Pathway Regulation Of Non-motile Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Establishment Of Melanosome Localization Regulation Of Response To Food Sperm Flagellum Assembly Regulation Of Cilium Beat Frequency Photoreceptor Cell Outer Segment Organization Melanosome Localization Microtubule Cytoskeleton Organization Response To Leptin Brain Morphogenesis Microtubule Anchoring Striatum Development Melanosome Transport Ventricular System Development Face Development Pigment Granule Transport Dynactin Binding Retina Homeostasis Microtubule Anchoring At Microtubule Organizing Center Regulation Of Appetite Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Nuclear Body Organization Reproductive System Development Phosphatidylinositol-5-phosphate Binding Centriole Replication	RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Androgen Binding Mitochondrial Outer Membrane Meiotic Cytokinesis Formin-nucleated Actin Cable Assembly Parallel Actin Filament Bundle Assembly Establishment Of Meiotic Spindle Localization Polar Body Extrusion After Meiotic Divisions Cleavage Furrow Formation Actin Filament Network Formation Broken Chromosome Clustering
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