DPYSL5 and DPYSL3

Number of citations of the paper that reports this interaction (PubMedID 10956643)
0

Data Source:
HPRD (in vivo)

		DPYSL5	DPYSL3
Description		dihydropyrimidinase like 5	dihydropyrimidinase like 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Protein-containing Complex Neuronal Cell Body Synapse Glutamatergic Synapse	Extracellular Space Cytoplasm Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Projection Cell Body Synapse Exocytic Vesicle
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides SH3 Domain Binding Filamin Binding Chondroitin Sulfate Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis	Pyrimidine Nucleobase Catabolic Process Nervous System Development Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Neuron Development Response To Axon Injury Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus
Pathways		CRMPs in Sema3A signaling	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Obesity-related traits ( 23251661) Reflection (response to stress) ( 30886212) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Excessive daytime sleepiness ( 27992416) Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: APPL1 CFAP161 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FBN2 FES HSPA5	8 interacting genes: ACD DISC1 DPYSL5 HYOU1 OTUD6A POT1 TERF1 TNIK
Entrez ID		56896	1809
HPRD ID		10522	03104
Ensembl ID		ENSG00000157851	ENSG00000113657
Uniprot IDs		Q9BPU6	A0A140VK07 Q14195 Q6DEN2 Q8IXW6
PDB IDs		4B90 4B91 4B92	4BKN 4CNS 4CNT 4CNU
Enriched GO Terms of Interacting Partners?		Dihydropyrimidinase Activity Pyrimidine Nucleobase Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Pyrimidine Nucleobase Metabolic Process Pyrimidine-containing Compound Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Pyrimidine-containing Compound Metabolic Process Filamin Binding Regulation Of Cell Motility Regulation Of Locomotion Nucleobase-containing Small Molecule Metabolic Process Phosphoprotein Binding Maintenance Of Protein Location Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Small Molecule Metabolic Process Hydrolase Activity Uracil Catabolic Process Maintenance Of Location Cerebellum Structural Organization Positive Regulation Of Macropinocytosis Aspartyl-tRNA Aminoacylation Aspartate-tRNA Ligase Activity Thymine Metabolic Process Thymine Catabolic Process Regulation Of Cell Migration Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Phosphatidylinositol Binding Asparaginyl-tRNA Aminoacylation Cytoplasm CMP Catabolic Process DUMP Catabolic Process Regulation Of ATF6-mediated Unfolded Protein Response UMP Catabolic Process Catabolic Process DCMP Catabolic Process Macropinosome Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Nervous System Development Pyrimidine Ribonucleotide Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pinocytosis Bone Trabecula Formation Post-translational Protein Targeting To Membrane, Translocation Adiponectin-activated Signaling Pathway	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Positive Regulation Of Telomere Maintenance Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Telomere Maintenance Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Cellular Component Organization Chromosome, Telomeric Region Regulation Of Chromosome Organization Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Chromosome Organization Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding System Development Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Projection Development
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