UBQLN4 and AREG

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBQLN4	AREG
Description		ubiquilin 4	amphiregulin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Protein-containing Complex Perinuclear Region Of Cytoplasm Site Of DNA Damage	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Autophagy DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Autophagosome Maturation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Glial Cell Proliferation Neuron Projection Development Response To Estradiol ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphorylation Response To Hydrogen Peroxide Response To Peptide Hormone Negative Regulation Of Osteoblast Differentiation Response To Glucocorticoid Response To CAMP Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Pathways			PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling NFE2L2 regulating tumorigenic genes Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 23128233 28067908)	Blond vs. brown/black hair color ( 30531825) Breast size ( 22747683 27182965) Mammographic density (dense area) ( 25342443) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)
Interacting Genes		163 interacting genes: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATP5IF1 ATP5MK ATXN1 BAG6 BPIFA1 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD274 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CSTPP1 CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GJA1 GJA5 GJC1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MTNR1B MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NLA NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLAAT3 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBC UBQLN1 UBQLN2 UBR7 UNC119 UROS VIP WAC WWP2 YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205	10 interacting genes: APP CCND3 CYSRT1 DNAAF10 EGFR KRTAP10-3 KRTAP10-8 MMP9 UBQLN4 WT1
Entrez ID		56893	374
HPRD ID		05670	00093
Ensembl ID		ENSG00000160803	ENSG00000109321
Uniprot IDs		B4DZF6 Q59F94 Q9NRR5	P15514
PDB IDs			2RNL
Enriched GO Terms of Interacting Partners?		Protein Binding Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Transport SA Node Cell To Atrial Cardiac Muscle Cell Communication Protein Folding Extracellular Space Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Cardiac Muscle Tissue Development AV Node Cell To Bundle Of His Cell Communication Positive Regulation Of Proteolysis Protein Disulfide Isomerase Activity Gap Junction Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Communication Involved In Cardiac Conduction Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Macroautophagy Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Cell Communication Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of Fat Cell Differentiation Tissue Development Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Neutrophil Migration Negative Regulation Of Cell Population Proliferation Endoplasmic Reticulum Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of Response To Endoplasmic Reticulum Stress ESCRT-0 Complex Positive Regulation Of Protein Metabolic Process Regulation Of Biological Quality Regulation Of Membrane Potential Positive Regulation Of Catabolic Process Regulation Of Proteolysis Positive Regulation Of Macroautophagy Collagen Binding Establishment Of Protein Localization MRNA Cleavage And Polyadenylation Specificity Factor Complex Peptidase Inhibitor Complex	Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Response To UV-A Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Amyloid-beta Complex Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Cellular Response To Oxygen-containing Compound Response To Light Stimulus Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Cell Cycle Extracellular Matrix Organization Positive Regulation Of Protein Import Extracellular Structure Organization Response To CAMP Identical Protein Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of MiRNA Transcription Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Nuclear Proteasome Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Population Proliferation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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