CFAP298 and FMN2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CFAP298	FMN2
Description		cilia and flagella associated protein 298	formin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Spindle Cytosol Cytoskeleton Plasma Membrane Microvillus Cell Cortex Actin Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Protein Binding	Molecular_function Actin Binding
	Biological Process	Regulation Of Cilium Movement Cilium Assembly	DNA Damage Response Protein Transport Vesicle-mediated Transport Meiotic Chromosome Movement Towards Spindle Pole Cell Migration Actin Cytoskeleton Organization Intracellular Signal Transduction Polar Body Extrusion After Meiotic Divisions Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Intracellular Transport Oogenesis Actin Filament Bundle Assembly Establishment Of Meiotic Spindle Localization Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Formin-nucleated Actin Cable Assembly Cellular Response To Hypoxia Positive Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Anger ( 24489884) Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23437003) Bone mineral density (Ward's triangle area) ( 27397699) Bullous pemphigoid ( 34011352) Carotid plaques in rheumatoid arthritis ( 30251476) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Platelet count ( 32888494) Plateletcrit ( 32888494) Rapid automised naming of letters ( 30741946) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 30498476) Urate levels in obese individuals ( 25811787)
Interacting Genes		21 interacting genes: APP COPS5 ERBB2 EWSR1 FMN2 GMCL1 KPNA4 MAPK6 NCOA2 PAX6 PTGER4 RANBP9 RFX5 RPH3A SNRNP70 SPTBN4 TAF1 TRPS1 UNC13B ZNF521 ZNF624	4 interacting genes: CDC42 CFAP298 RAC1 RHOA
Entrez ID		56683	56776
HPRD ID		10756	10449
Ensembl ID		ENSG00000159079	ENSG00000155816
Uniprot IDs		C9J818 D3DSE6 P57076	Q9HBL1 Q9NZ56
PDB IDs			2YLE 3R7G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Axonogenesis Neuromuscular Junction Development Nucleoplasm Secretion By Cell Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Neuron Fate Commitment Establishment Of Organelle Localization Negative Regulation Of Eosinophil Extravasation Positive Regulation Of Androgen Receptor Signaling Pathway Transcription Regulator Inhibitor Activity Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Locomotory Behavior MRNA Transcription By RNA Polymerase II Establishment Of Localization In Cell Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Regulation Of Stress Fiber Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Cell-substrate Adhesion GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Postsynapse Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Regulation Of Synapse Organization Positive Regulation Of Lamellipodium Organization GTPase Activity Cell Projection Regulation Of Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis GTP Binding Actin Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
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