TRIM39 and PDLIM5

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM39	PDLIM5
Description		tripartite motif containing 39	PDZ and LIM domain 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Stress Fiber Cytoplasm Cytosol Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Filamentous Actin Cell Projection Synapse Presynapse Postsynapse
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Kinase C Binding Protein Binding Actinin Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Heart Development Actin Cytoskeleton Organization Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Muscle Structure Development Cell-cell Adhesion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neurexins and neuroligins
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lewy body disease ( 25188341) Mean platelet volume ( 27863252 32888494) Myocardial infarction ( 33532862) PR interval ( 32439900) Prostate cancer ( 19767753) Pulse pressure ( 30578418) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Uterine fibroids ( 31649266) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		62 interacting genes: APP BTNL2 CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	16 interacting genes: ACTB ACTN1 CACNA1B CCDC136 COIL DSCAM GFI1B KRT40 KRTAP10-7 NOD2 PCDH7 PRKCB PRKCE PRKCG TRIM39 ZYX
Entrez ID		56658	10611
HPRD ID		09298	05799
Ensembl ID		ENSG00000204599	ENSG00000163110
Uniprot IDs		A0A024RCP5 Q9HCM9	A0A0A0MSP3 B7Z481 B7Z8X5 Q96HC4
PDB IDs		2DID 2DIF 2ECJ	2DAR 2UZC
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Catabolic Process Nucleus Protein Binding Nucleoplasm Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin Binding Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Modification Process Cysteine-type Deubiquitinase Activity Transferase Activity Protein Deubiquitination Positive Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Negative Regulation Of Protein Deubiquitination ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex DNA Repair Cytosol Protein K6-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process	Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Cell Adhesion Synapse Regulation Of Neurotransmitter Secretion Response To Morphine Cell-cell Signaling Signaling Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Regulation Of Canonical NF-kappaB Signal Transduction Trans-synaptic Signaling Cell Communication Synaptic Signaling Positive Regulation Of Synaptic Transmission Presynaptic Cytosol Plasma Membrane Cell-cell Adhesion Cell-cell Junction Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Cytochalasin B Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Protein Ubiquitination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding ATP Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Brush Border Regulation Of Vesicle-mediated Transport Regulation Of Post-translational Protein Modification Cytoskeleton Cell Junction Assembly Regulation Of Norepinephrine Uptake Homotypic Cell-cell Adhesion Actin Filament Bundle Organization Actin Filament Bundle Assembly Structural Constituent Of Postsynapse Regulation Of Secretion By Cell Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Histone H3T6 Kinase Activity Ethanol Binding Negative Regulation Of Proteasomal Protein Catabolic Process Detection Of Peptidoglycan
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