TMPRSS4 and BNIP3L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMPRSS4	BNIP3L
Description		transmembrane serine protease 4	BCL2 interacting protein 3 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Secretory Granule	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Nuclear Speck
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Response To Wounding Regulation Of Gene Expression Protein Processing Negative Regulation Of Growth Rate Positive Regulation Of Viral Entry Into Host Cell	Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Mitochondrial Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Defense Response To Virus Cellular Response To Hypoxia Mitochondrial Outer Membrane Permeabilization Regulation Of Mitophagy Regulation Of Protein Targeting To Mitochondrion
Pathways			TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Schizophrenia ( 28991256 30285260)
Interacting Genes		15 interacting genes: BNIP3L CLEC7A CLRN1 ERVFRD-1 FAM209A FNDC9 GPX8 KASH5 LMNA NLRX1 RASGRP4 SIGLEC12 SUSD3 SYNE4 TMEM79	37 interacting genes: ADIPOQ BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 CYB5B DOK5 DUSP3 ECM1 EWSR1 FATE1 FBXL4 GABARAPL1 GABARAPL2 GBP2 GNB5 HTR2B KEAP1 KLHL23 LDLRAD1 LMNA MALL MAP1LC3A NGFR RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11 TMEM120B TMEM132D TMPRSS4 TNMD
Entrez ID		56649	665
HPRD ID		05952	07288
Ensembl ID		ENSG00000137648	ENSG00000104765
Uniprot IDs		A0AAQ5BHV4 B7Z458 B7Z8X1 B7Z900 E7ESG9 Q9NRS4	O60238 Q6IBV1
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Envelope Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Membrane Neuron Apoptotic Process Mitochondrial Membrane Organization Phosphatidylethanolamine Binding Mitochondrial Outer Membrane Dendritic Cell Apoptotic Process Macroautophagy Ubiquitin Protein Ligase Binding Autophagy Vacuole Organization Autophagosome Assembly Response To Nutrient Levels BH3 Domain Binding Autophagosome Organization Negative Regulation Of Autophagy Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxidative Stress Protein Binding Regulation Of Autophagy Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Respiratory Burst Autophagosome Maturation Mitochondrion Organization Cellular Response To Nutrient Levels Identical Protein Binding Autophagosome Membrane Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Regulation Of Mitochondrial Membrane Permeability Response To Oxygen-glucose Deprivation Regulation Of Endothelial Cell Proliferation Nuclear Lamina Regulation Of Locomotion Cellular Response To Oxygen Levels Negative Regulation Of Apoptotic Process Chemical Homeostasis Response To Stress Apoptotic Mitochondrial Changes Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Apoptotic Process Response To Decreased Oxygen Levels Negative Regulation Of Programmed Cell Death GABA Receptor Binding
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