CYP26B1 and PCYOX1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)

		CYP26B1	PCYOX1
Description		cytochrome P450 family 26 subfamily B member 1	prenylcysteine oxidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Lysosome Very-low-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding All-trans Retinoic Acid 18-hydroxylase Activity	Prenylcysteine Oxidase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Oxygen As Acceptor FAD Binding Farnesylcysteine Lyase Activity
	Biological Process	Cell Fate Determination Establishment Of T Cell Polarity Kidney Development Lipid Metabolic Process Vitamin Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Male Meiotic Nuclear Division Spermatogenesis Central Nervous System Development Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Embryonic Limb Morphogenesis Response To Retinoic Acid Response To Vitamin A Retinoic Acid Catabolic Process Retinoic Acid Metabolic Process Tongue Morphogenesis Regulation Of T Cell Differentiation Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Morphogenesis Establishment Of Skin Barrier Cornification Cellular Response To Retinoic Acid Positive Regulation Of Tongue Muscle Cell Differentiation	Prenylated Protein Catabolic Process Prenylcysteine Catabolic Process
Pathways		Vitamins RA biosynthesis pathway Defective CYP26B1 causes RHFCA
Drugs		Tretinoin
Diseases
GWAS		Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Heel bone mineral density ( 30598549) Height ( 31562340) IgA levels ( 28628107) Malaria ( 31844061) Mitochondrial heteroplasmy measurement ( 33731350) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Schizophrenia ( 25056061) Serum metabolite levels ( 33031748)	Acne (severe) ( 24927181) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Male-pattern baldness ( 28196072) Morning person ( 30696823)
Interacting Genes		5 interacting genes: CEBPG GMCL1 GTF2H2 NEDD4L PCYOX1	4 interacting genes: CYP26B1 HOXA1 MPHOSPH10 OGT
Entrez ID		56603	51449
HPRD ID		05550	11422
Ensembl ID		ENSG00000003137	ENSG00000116005
Uniprot IDs		E7ER08 Q9NR63	Q9UHG3
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Internalization Prenylcysteine Oxidase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Oxygen As Acceptor Prenylcysteine Catabolic Process Farnesylcysteine Lyase Activity Prenylated Protein Catabolic Process Receptor-mediated Endocytosis Core TFIIH Complex Portion Of Holo TFIIH Complex Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Enucleate Erythrocyte Differentiation Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity	Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Response To Nutrient All-trans Retinoic Acid 18-hydroxylase Activity Positive Regulation Of Tongue Muscle Cell Differentiation Retinoic Acid Catabolic Process Protein O-acetylglucosaminyltransferase Activity Mpp10 Complex Positive Regulation Of Skeletal Muscle Fiber Differentiation Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Transcription By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Sno(s)RNA-containing Ribonucleoprotein Complex Tongue Morphogenesis Retinoic Acid 4-hydroxylase Activity Cornification Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Skeletal Muscle Fiber Differentiation Establishment Of T Cell Polarity NSL Complex Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Response To Vitamin A Positive Regulation Of Myotube Differentiation Regulation Of Retinoic Acid Receptor Signaling Pathway Embryonic Morphogenesis Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Response To Nutrient Levels Retinoic Acid Binding Sin3-type Complex Regulation Of Skeletal Muscle Cell Differentiation Retinoic Acid Receptor Signaling Pathway Histone Acetyltransferase Complex Inflammatory Response Cochlea Morphogenesis Regulation Of Protein Localization To Synapse Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid Metabolic Process Proximal/distal Pattern Formation Vitamin Metabolic Process
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