EIF4ENIF1 and EHMT2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EIF4ENIF1	EHMT2
Description		eukaryotic translation initiation factor 4E nuclear import factor 1	euchromatic histone lysine methyltransferase 2
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3K56 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Synaptonemal Complex Assembly Spermatid Development Cellular Response To Starvation Fertilization Peptidyl-lysine Dimethylation Methylation Organ Growth Phenotypic Switching Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Behavioral Response To Cocaine Oocyte Development Neuron Fate Specification Cellular Response To Cocaine Negative Regulation Of Autophagosome Assembly
Pathways			Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	A body shape index ( 34021172) Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 23760081 25802187) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		93 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NIN NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6	65 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA BBS9 CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EIF4ENIF1 EPDR1 ESR1 ESS2 EXOSC7 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MAZ MX2 NAA10 NAA11 NAPRT PLOD3 POR PRPF6 PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 UBASH3A VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837
Entrez ID		56478	10919
HPRD ID		10456	06854
Ensembl ID		ENSG00000184708	ENSG00000204371
Uniprot IDs		Q9NRA8	A0A024RCN9 A2ABF8 A2ABF9 B7Z852 Q59FM7 Q96KQ7
PDB IDs		5ANR 6F9W 6X2R	2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1 7BTV 7BUC 7DCF 7T7L 7X73 7XUA 7XUB 7XUC 7XUD 8VV8 8Z7C 8Z7D 8Z7E
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity	Nucleus DNA Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleosome Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of RNA Biosynthetic Process Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Zinc Ion Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein-DNA Complex Assembly Nucleosome Organization Protein Binding Euchromatin Metal Ion Binding Negative Regulation Of Transcription By RNA Polymerase II Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein N-terminal-serine Acetyltransferase Activity Chromosome Organization NatA Complex Chromatin Protein-N-terminal Amino-acid Acetyltransferase Activity Chromosome Protein Heterodimerization Activity Cellular Component Assembly RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleosomal DNA Binding Establishment Of Protein Localization To Chromatin Positive Regulation Of Biosynthetic Process TFIID-class Transcription Factor Complex Binding
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