LTB4R2 and GPR146

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		LTB4R2	GPR146
Description		leukotriene B4 receptor 2	G protein-coupled receptor 146
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	G Protein-coupled Receptor Activity
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Virus Response To Type II Interferon Response To Interferon-beta Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Defense Response To Virus
Pathways		Leukotriene receptors G alpha (q) signalling events
Drugs		Amelubant Leukotriene B4
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)	Cholesterol, total ( 24097068)
Interacting Genes		48 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MUC1 MYO1E OBSL1 P4HTM PER1 PIGM PKD1 PTGIS RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	2 interacting genes: GPR35 LTB4R2
Entrez ID		56413	115330
HPRD ID		16153	17064
Ensembl ID		ENSG00000213906	ENSG00000164849
Uniprot IDs		B4E292 Q9NPC1	A4D2Q3 B4DTD6 Q96CH1
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	G Protein-coupled Receptor Activity Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Keratinocyte Migration Negative Regulation Of Adenylate Cyclase Activity Regulation Of Voltage-gated Calcium Channel Activity G Protein-coupled Receptor Signaling Pathway Chemokine Receptor Activity Negative Regulation Of Transporter Activity Epithelial Cell Migration Negative Regulation Of Calcium Ion Transmembrane Transport G Protein-coupled Peptide Receptor Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transmembrane Transporter Activity Chemokine-mediated Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transporter Activity Negative Regulation Of Monoatomic Ion Transport Neuropeptide Signaling Pathway Negative Regulation Of Transmembrane Transport Ameboidal-type Cell Migration Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Catalytic Activity Regulation Of Calcium Ion Transport
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