LGMN and LAMC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LGMN	LAMC3
Description		legumain	laminin subunit gamma 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Late Endosome Endolysosome Lumen Lysosomal Lumen Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Basement Membrane Membrane Extracellular Matrix
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Tau Protein Binding Endopeptidase Activator Activity	Structural Molecule Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Renal System Process Proteolysis Vacuolar Protein Processing Memory Positive Regulation Of Cell Population Proliferation Associative Learning Response To Acidic PH Negative Regulation Of Gene Expression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Catabolic Process Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Multicellular Organism Growth Vitamin D Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Maturation Cellular Response To Calcium Ion Positive Regulation Of Monocyte Chemotaxis Dendritic Spine Organization Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of ERBB Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Chemotaxis	Cell Morphogenesis Cell Adhesion Visual Perception Astrocyte Development Retina Development In Camera-type Eye
Pathways		Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Change in serum metabolite levels (CMS) ( 31636271) Systemic juvenile idiopathic arthritis ( 27927641)	Alcohol consumption (max-drinks) ( 29460428) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Degraded stimulus continuous performance test score ( 31596458) Endometriosis ( 28333195) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 27749845) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		7 interacting genes: AMPH FBLN5 LAMC3 MAPT SET SRPK2 USP17L2	20 interacting genes: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		5641	10319
HPRD ID		04017	05069
Ensembl ID		ENSG00000100600	ENSG00000050555
Uniprot IDs		Q53XC6 Q96CY7 Q99538	Q8N2D6 Q9Y6N6
PDB IDs		4AW9 4AWA 4AWB 4FGU 4N6N 4N6O 5LU8 5LU9 5LUA 5LUB 7FQH 7FQI 7FQJ 7FQK 7FQL 7O50 8AE4 8AE5
Enriched GO Terms of Interacting Partners?		Regulation Of Superoxide Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Intramembranous Bone Growth	Acute-phase Response Blood Microparticle Acute Inflammatory Response Response To Bacterium Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage
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