MAPK13 and ANKLE2

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		MAPK13	ANKLE2
Description		mitogen-activated protein kinase 13	ankyrin repeat and LEM domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Kinase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	MAPK Cascade Response To Osmotic Stress Positive Regulation Of Interleukin-6 Production Cellular Response To Stress Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	Mitotic Nuclear Membrane Reassembly Nervous System Development Central Nervous System Development Nuclear Membrane Reassembly Negative Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Cell Division
Pathways		NOD1/2 Signaling Pathway p38MAPK events VEGFA-VEGFR2 Pathway	Initiation of Nuclear Envelope (NE) Reformation RAC2 GTPase cycle RHOG GTPase cycle
Drugs		Minocycline KC706 Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576) Offspring birth weight ( 31043758)	Adult body size ( 32376654) Immune response to smallpox vaccine (IL-6) ( 22542470) Lymphocyte count ( 32888494) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: AKIP1 ANKLE2 APP ATF2 BTRC EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	3 interacting genes: MAPK13 ZFYVE9 ZNF512B
Entrez ID		5603	23141
HPRD ID		09113	19309
Ensembl ID		ENSG00000156711	ENSG00000176915
Uniprot IDs		A0A024RD04 O15264	Q86XL3
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO 8X23
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction MAP Kinase Kinase Activity P38MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Response To Growth Factor Main Axon Cellular Response To Nerve Growth Factor Stimulus Calcium-dependent Protein Serine/threonine Kinase Activity Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Brain-derived Neurotrophic Factor Stimulus Protein Serine/threonine Kinase Activity Calmodulin Binding Protein-containing Complex Adult Locomotory Behavior Developmental Process Regulation Of Cell Communication Signal Transduction Negative Regulation Of Ferroptosis Regulation Of Ferroptosis Protein Kinase Activity Apolipoprotein Binding Identical Protein Binding Astrocyte Activation Apoptotic Process Response To Lead Ion Regulation Of Superoxide Anion Generation Regulation Of Signal Transduction Programmed Cell Death Cell Death Nucleus Positive Regulation Of Superoxide Anion Generation Immune System Process Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Positive Regulation Of Long-term Synaptic Potentiation Kinase Activity Regulation Of Programmed Cell Death Protein Serine Kinase Activity Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Protein Phosphatase 2A Binding Immune Response-activating Signaling Pathway Response To Oxidative Stress Central Nervous System Development	Response To Anisomycin Cellular Response To Anisomycin Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sorbitol Cellular Response To Sodium Arsenite Response To Sorbitol MAP Kinase Activity Cellular Response To Arsenic-containing Substance 1-phosphatidylinositol Binding Response To Salt Response To Arsenic-containing Substance Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of MiRNA Transcription
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