GNG12 and GNB3

Number of citations of the paper that reports this interaction (PubMedID 22940628)
53

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		GNG12	GNB3
Description		G protein subunit gamma 12	G protein subunit beta 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome	Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding G-protein Beta-subunit Binding	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Spectrin Binding GTPase Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Feeding Behavior Regulation Of Cholesterol Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Phospholipid Metabolic Process
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Thyroid stimulating hormone levels ( 32769997) Upper eyelid morphology ( 29921221)	Central retinal vein equivalent ( 26567291) High myopia ( 31816047 33830181) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		7 interacting genes: CAPN1 FHL2 GNB1 GNB2 GNB3 GNB4 HDAC7	12 interacting genes: CIDEB DMBT1 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNG8 GRK2 RASD2 TGFBR1
Entrez ID		55970	2784
HPRD ID		13592	00743
Ensembl ID		ENSG00000172380	ENSG00000111664
Uniprot IDs		Q9UBI6	E9PCP0 F1T0G5 P16520
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Protein-containing Complex Binding Lysosomal Membrane Extracellular Exosome Focal Adhesion Atrial Cardiac Muscle Cell Development Calpain Complex Cytoplasm Mammary Gland Involution NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior	G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Synapse Signal Transduction Membrane GTPase Activity Plasma Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Zymogen Binding Cellular Response To Pheromone Edg-2 Lysophosphatidic Acid Receptor Binding PDZ Domain Binding Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Response To Pheromone
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?