ERBIN and ATP2B4

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ERBIN	ATP2B4
Description		erbb2 interacting protein	ATPase plasma membrane Ca2+ transporting 4
Image
GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization	Mitochondrion Plasma Membrane Caveola Cilium Membrane Basolateral Plasma Membrane Z Disc T-tubule Motile Cilium Protein-containing Complex Ciliary Basal Body Sperm Flagellum Sarcolemma Cell Projection Intracellular Membrane-bounded Organelle Membrane Raft Presynaptic Active Zone Membrane Sperm Principal Piece Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Sodium Channel Regulator Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Transport Across Blood-brain Barrier Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Ritodrine Halothane Desflurane Sevoflurane
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Appendicular lean mass ( 33097823) Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Glycated hemoglobin levels ( 34059833) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494 27863252) Malaria ( 22895189 31844061) Mean corpuscular hemoglobin concentration ( 23263863 27863252 32888494 28453575) Mean corpuscular volume ( 27863252 32888494) Monocyte count ( 32888494) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		68 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG CWC27 DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 KEAP1 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC
Entrez ID		55914	493
HPRD ID		06090	00159
Ensembl ID		ENSG00000112851	ENSG00000058668
Uniprot IDs		A0A8V8TML4 A0A8V8TPC7 Q96RT1	P23634
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL	1CFF 2KNE
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation	Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Cell Adhesion GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity GDP Metabolic Process Protein Localization To Synapse Cell Junction Protein Localization To Cell Junction Basolateral Plasma Membrane Kinase Binding Postsynaptic Density Membrane GMP Metabolic Process Synaptic Signaling Regulation Of Biological Quality Positive Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Adherens Junction Cell-cell Junction Synapse Scaffold Protein Binding Regulation Of Transport Plasma Membrane Regulation Of Vesicle-mediated Transport Nucleoside Monophosphate Metabolic Process Postsynaptic Density Ribonucleoside Diphosphate Metabolic Process Regulation Of System Process Glutamatergic Synapse Nucleoside Diphosphate Metabolic Process Cell-cell Signaling Basement Membrane Juxtaparanode Region Of Axon Signaling Intracellular Protein Localization Cell Periphery Regulation Of Endocytosis Cell Communication Chemical Synaptic Transmission Protein Localization To Membrane Cellular Response To Potassium Ion Sarcolemma Neuron Projection Trans-synaptic Signaling Regulation Of Metal Ion Transport
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