PSENEN and CRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSENEN	CRB3
Description		presenilin enhancer, gamma-secretase subunit	crumbs cell polarity complex component 3
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex	Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Enzyme Binding Endopeptidase Activator Activity	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs		E-2012
Diseases		Acne inversa; Hidradenitis supprativa
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: APH1A CRB3 CREB3 NCSTN PSEN1 PSEN2 SLC10A2 SLC10A6 THBD TMED10	28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6
Entrez ID		55851	92359
HPRD ID		06362	16749
Ensembl ID		ENSG00000205155	ENSG00000130545
Uniprot IDs		Q9NZ42	Q9BUF7
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8OQY 8OQZ 8X52 8X53 8X54	5I7Z
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Protein Processing Synaptic Membrane Notch Signaling Pathway Protein Maturation Golgi Membrane Presynaptic Membrane Synaptic Vesicle Growth Factor Receptor Binding Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Membrane Early Endosome Membrane Protein Intracellular Domain Proteolysis Golgi Apparatus Vesicle Targeting Plasma Membrane Endopeptidase Activator Activity Bile Acid And Bile Salt Transport Endoplasmic Reticulum Membrane Positive Regulation Of Coagulation Proteolysis Azurophil Granule Membrane Carboxylic Acid Transport Organic Acid Transport Cerebellum Development Negative Regulation Of Core Promoter Binding Positive Regulation Of Deacetylase Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Amyloid Precursor Protein Biosynthetic Process Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Protein-containing Complex Organic Anion Transport ATPase Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Endopeptidase Activity Cajal-Retzius Cell Differentiation Blood Coagulation, Common Pathway Symporter Activity	Endoplasmic Reticulum Membrane SNAP Receptor Activity Membrane SNARE Complex Heme Oxidation Heme Oxygenase (decyclizing) Activity Vesicle Fusion Organelle Membrane Fusion Golgi Apparatus Endomembrane System Organelle Fusion Vesicle Fusion With Golgi Apparatus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Endoplasmic Reticulum Establishment Or Maintenance Of Apical/basal Cell Polarity Heme Catabolic Process Membrane Fusion Porphyrin-containing Compound Catabolic Process Myelin Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Organization Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Amyloid Fibril Formation Apical Junction Complex Bicellular Tight Junction Protein Binding Autophagy Heme Metabolic Process Vesicle Organization Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Protein Localization To Myelin Sheath Abaxonal Region Tight Junction Porphyrin-containing Compound Metabolic Process Macroautophagy Establishment Or Maintenance Of Cell Polarity
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