USE1 and CCM2L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USE1	CCM2L
Description		unconventional SNARE in the ER 1	CCM2 like scaffold protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane COPI-coated Vesicle SNARE Complex	Cellular_component
	Molecular Function	SNAP Receptor Activity Protein Binding	Molecular_function Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum Organization Lysosomal Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Secretion By Cell Regulation Of ER To Golgi Vesicle-mediated Transport Membrane Fusion Endoplasmic Reticulum Tubular Network Organization	Heart Morphogenesis Biological_process
Pathways		COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Night sleep phenotypes ( 27126917)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Migraine ( 27322543)
Interacting Genes		18 interacting genes: APOL2 APP AQP6 BSCL2 CALN1 CCDC70 CCM2L CREB3 EBP JAGN1 LMNA MEOX2 SCN3B SLC71A2 STX1A STX4 TMEM86B TRIM27	4 interacting genes: CAMK2B PBX4 PSMB1 USE1
Entrez ID		55850	140706
HPRD ID		11299	12753
Ensembl ID		ENSG00000053501	ENSG00000101331
Uniprot IDs		Q9NZ43	Q9NUG4
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Lipoprotein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Positive Regulation Of Synaptic Transmission Response To Fungus Regulation Of Protein Localization Lipoprotein Particle Regulation Of Protein Transport Positive Regulation Of Monocyte Chemotaxis Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Identical Protein Binding PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Membrane Structural Constituent Of Nuclear Lamina Protein Sumoylation SNARE Complex Regulation Of Insulin Secretion Insulin Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Peptide Hormone Secretion SNARE Complex Assembly SNAP Receptor Activity Myosin Head/neck Binding SNARE Binding Vesicle Docking Exocytosis Positive Regulation Of Eosinophil Degranulation Sphingomyelin Phosphodiesterase Activator Activity Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Storage Vacuole Endoplasmic Reticulum Membrane Positive Regulation Of Deacetylase Activity
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