WWC3 and WWC2

Number of citations of the paper that reports this interaction (PubMedID 24682284)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		WWC3	WWC2
Description		WWC family member 3	WW and C2 domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity	Protein Binding Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth
Pathways
Drugs
Diseases
GWAS		Mild influenza (H1N1) infection ( 26379185) Prostate cancer ( 23535732)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Heel bone mineral density ( 30598549) Height ( 20881960 28552196) Initial alcohol sensitivity ( 30276832)
Interacting Genes		5 interacting genes: APP CIP2A WBP2 WWC1 WWC2	5 interacting genes: CRYAA REPS1 WWC1 WWC3 YWHAQ
Entrez ID		55841	80014
HPRD ID		11136	12529
Ensembl ID		ENSG00000047644	ENSG00000151718
Uniprot IDs		Q9ULE0	Q6AWC2
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Hippo Signaling Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Organ Growth Signaling Adaptor Activity Negative Regulation Of Developmental Growth Kinase Binding Regulation Of Growth Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Regulation Of Intracellular Signal Transduction Positive Regulation Of G Protein-coupled Receptor Internalization Broken Chromosome Clustering Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Molecular Adaptor Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Negative Regulation Of Growth Regulation Of Transcription By RNA Polymerase II	Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth Regulation Of Hippo Signaling Signaling Adaptor Activity Kinase Binding Regulation Of Organ Growth Negative Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Molecular Adaptor Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Growth Lens Fiber Cell Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Tubulin Complex Assembly Negative Regulation Of Metabolic Process Cytosol Response To UV-A Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Developmental Growth Lens Morphogenesis In Camera-type Eye Embryonic Camera-type Eye Morphogenesis Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transport Structural Constituent Of Eye Lens Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Hippo Signaling Apoptotic Process Involved In Morphogenesis
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