EAPP and TNFAIP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EAPP	TNFAIP8
Description		E2F associated phosphoprotein	TNF alpha induced protein 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II	Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways			PI Metabolism
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Insulin-related traits (multivariate analysis) ( 32002517) Metabolite levels ( 23823483)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059 31959851 31619474 31361310) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Heschl's gyrus morphology ( 25130324) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Plantar fascial disorders ( 29534260) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 28552196) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: AAR2 BYSL TNFAIP8 UBE3A UBQLN4	11 interacting genes: ATN1 EAF1 EAPP INO80E MED4 PLEKHF1 PLEKHF2 PRR13 SDCBP TIFA TMEM132D
Entrez ID		55837	25816
HPRD ID		12631	18204
Ensembl ID		ENSG00000129518	ENSG00000145779
Uniprot IDs		Q56P03	B3KUI2 O95379
PDB IDs
Enriched GO Terms of Interacting Partners?		Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Sperm Entry Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Ubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Protein K48-linked Ubiquitination Regulation Of CD40 Signaling Pathway B-1 B Cell Homeostasis Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cellular PH Reduction Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex Regulation Of Germinal Center Formation Regulation Of Post-translational Protein Modification Intracellular Receptor Signaling Pathway Preribosome, Small Subunit Precursor Regulation Of Protein Localization To Nucleolus Protein Polyubiquitination Regulation Of Toll-like Receptor 3 Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Chronic Inflammatory Response Positive Regulation Of Hepatocyte Proliferation Ubiquitin-protein Transferase Activity Progesterone Receptor Signaling Pathway Prostate Gland Growth K48-linked Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Vascular Wound Healing Negative Regulation Of Bone Resorption Regulation Of Hepatocyte Proliferation Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagosome Maturation Proteolysis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Negative Regulation Of Bone Remodeling K63-linked Deubiquitinase Activity Trophectodermal Cell Differentiation Tolerance Induction	Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation
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