CDK5RAP2 and CDK5R1

Number of citations of the paper that reports this interaction (PubMedID 11882646)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CDK5RAP2	CDK5R1
Description		CDK5 regulatory subunit associated protein 2	cyclin dependent kinase 5 regulatory subunit 1
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GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Gamma-tubulin Ring Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cell Junction Microtubule Plus-end Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Protein-containing Complex Binding	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs			Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)
Interacting Genes		28 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LRRK1 LUC7L2 MAGEH1 MAPRE1 MRRF NEFL PCBD1 PHF19 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	37 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HNF1B HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 SUZ12 TSC22D4 TTBK1
Entrez ID		55755	8851
HPRD ID		09740	04586
Ensembl ID		ENSG00000136861	ENSG00000176749
Uniprot IDs		A0A0A0MRG9 A0A8I5KXG0 A0A8I5QKL1 B3KVI2 B9EG74 Q96SN8	Q15078 Q8N619
PDB IDs		6X0V 8RX1 9G3Y 9G3Z 9G40 9H9P	1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Growth Cone Microtubule-based Process Protein Kinase 5 Complex Cytoskeleton Organization Cerebellum Development Establishment Of Organelle Localization Perikaryon Negative Regulation Of Motor Neuron Apoptotic Process Hippocampus Development Cell Projection Organization ESC/E(Z) Complex Regulation Of Motor Neuron Apoptotic Process Neuromuscular Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Axon Layer Formation In Cerebral Cortex Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cell Projection Regulation Of Nervous System Development Retrograde Axonal Transport Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Plus-end Binding Microtubule Plus-end Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Apoptotic Process Organelle Localization Regulation Of Microtubule-based Process Regulation Of Intracellular Transport Neuron Projection Regeneration Diol Metabolic Process Neuron Projection Development Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Binding Spinal Cord Development Endopeptidase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Targeting To Membrane Regulation Of Synapse Organization Organelle Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Postsynapse Organization Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Positive Regulation Of Microtubule Polymerization DNA Endoreduplication Pre-mRNA Catabolic Process Positive Regulation Of Neurotrophin Production	Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth
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