PRKAR1A and ARFGEF2

Number of citations of the paper that reports this interaction (PubMedID 12571360)
44

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PRKAR1A	ARFGEF2
Description		protein kinase cAMP-dependent type I regulatory subunit alpha	ARF guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Association of TriC/CCT with target proteins during biosynthesis
Drugs		(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)	Periventricular nodular heterotopia (PVNH)
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1	12 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A PTGIS SLC9A8
Entrez ID		5573	10564
HPRD ID		01786	09250
Ensembl ID		ENSG00000108946	ENSG00000124198
Uniprot IDs		B2R5T5 P10644	A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		5KJX 5KJY 5KJZ	3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding	Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis
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