PRKAG1 and TNFAIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRKAG1	TNFAIP1
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	TNF alpha induced protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex	Nucleus Cytoplasm Endosome Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Cellular Response To Nutrient Levels Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Import Into Nucleus Regulation Of Cell Cycle	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Immune Response Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	RND3 GTPase cycle RND2 GTPase cycle
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)	Low density lipoprotein cholesterol levels ( 29403010) Osteoprotegerin levels ( 25080503)
Interacting Genes		33 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KLHL20 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 PRKDC SHMT2 TEKT1 TNFAIP1 TUBA1C	32 interacting genes: ARMC7 ARNT CAPN7 CARD9 CDC37 CSNK2B DAPP1 EPHA2 EPM2AIP1 EXOSC5 FXR1 FXR2 HAT1 HEXIM2 KDM1A LNX1 NTAQ1 NXF1 POLR1C PRKAG1 PSMA1 RHOA RHOB RIN3 SMARCA2 SMARCB1 STK16 SUV39H1 SVIL TRIM54 ZDHHC17 ZMYND19
Entrez ID		5571	7126
HPRD ID		04118	01856
Ensembl ID		ENSG00000181929	ENSG00000109079
Uniprot IDs		F8VYY9 P54619	Q13829
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Keratin Filament Nucleotide-activated Protein Kinase Complex Intermediate Filament AMP-activated Protein Kinase Activity Carboxylic Acid Biosynthetic Process Cytosol Fatty Acid Biosynthetic Process Small Molecule Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Fatty Acid Metabolic Process Response To Prostaglandin E Protein Localization To Lipid Droplet Monocarboxylic Acid Metabolic Process Somite Specification Carboxylic Acid Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Organic Acid Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Sterol Biosynthetic Process Cellular Response To Glucose Starvation Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Phosphatidylethanolamine Biosynthetic Process Cul3-RING Ubiquitin Ligase Complex Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Homotetramerization HMG Box Domain Binding Regulation Of Carbohydrate Catabolic Process Response To Nutrient Levels L-serine Metabolic Process Hair Cycle Segment Specification Somite Development Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Protein Homooligomerization Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Protein Tetramerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylcholine Biosynthetic Process	Endothelial Tube Morphogenesis Protein Kinase Regulator Activity Regulation Of Modification Of Synaptic Structure Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cleavage Furrow Positive Regulation Of Cell Development Regulation Of Generation Of Precursor Metabolites And Energy BBAF Complex Epigenetic Regulation Of Gene Expression Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Multicellular Organismal Development Brahma Complex NpBAF Complex Regulation Of Modification Of Postsynaptic Structure Costamere Cytoplasm NBAF Complex Regulation Of Endothelial Cell Migration Protein Binding Translation Regulator Activity Regulation Of Cell Cycle Regulation Of Cell Development Cytoplasmic Stress Granule Postsynapse Epithelial Tube Morphogenesis Positive Regulation Of Cell Differentiation Cytosol Nucleus Regulation Of DNA Repair Blastocyst Hatching Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Size Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of T Cell Differentiation
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