VAC14 and C4orf33

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		VAC14	C4orf33
Description		VAC14 component of PIKFYVE complex	chromosome 4 open reading frame 33
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronotype ( 30696823) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Mosquito bite size ( 28199695) Neurofibrillary tangles ( 31497858) Number of sexual partners ( 30643258) Remission after SSRI treatment in MDD or openness ( 29559929) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		108 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KEAP1 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34	2 interacting genes: TRIP13 VAC14
Entrez ID		55697	132321
HPRD ID		07660	14049
Ensembl ID		ENSG00000103043	ENSG00000151470
Uniprot IDs		Q08AM6	Q8N1A6
PDB IDs		7K1Y
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	PAS Complex Oocyte Maturation Synaptonemal Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Meiotic Nuclear Division Meiosis I Synaptonemal Complex Organization Female Meiosis I Male Meiosis I Regulation Of Meiotic Nuclear Division Reciprocal Meiotic Recombination Homologous Recombination Meiotic Recombination Checkpoint Signaling Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Meiotic Cell Cycle Meiotic Cell Cycle Checkpoint Signaling Female Meiotic Nuclear Division Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Presynaptic Endosome Oogenesis Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Involved In Meiotic Cell Cycle Regulation Of Mitotic Sister Chromatid Separation Female Gamete Generation Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process Meiosis I Cell Cycle Process Meiotic Nuclear Division Regulation Of Chromosome Separation Regulation Of Receptor Internalization Negative Regulation Of Chromosome Organization Nuclear Division Identical Protein Binding Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Spermatid Development Phosphatidylinositol Biosynthetic Process Meiotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Receptor-mediated Endocytosis Transcription Coregulator Activity Regulation Of Chromosome Segregation Phosphatidylinositol Metabolic Process Regulation Of Nuclear Division Cell Maturation Late Endosome Membrane Negative Regulation Of Mitotic Cell Cycle Phase Transition
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