MREG and EIF1AD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MREG	EIF1AD
Description		melanoregulin	eukaryotic translation initiation factor 1A domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Melanosome Membrane Melanosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol Binding	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Melanocyte Differentiation Melanosome Localization Melanosome Transport Pigmentation Developmental Pigmentation Minus-end-directed Organelle Transport Along Microtubule Phagosome Maturation	Translational Initiation
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Coronary artery disease ( 32469254) Macular thickness ( 30535121) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Serum uric acid levels ( 32271837)
Interacting Genes		6 interacting genes: CFTR CPSF7 EIF1AD HNRNPLL MAP1LC3A PUF60	34 interacting genes: AP2M1 BEND7 CCDC106 CEP55 CEP76 DPPA2 DRC4 GCSAML GLYR1 GTF2H4 LNX1 MEOX2 MID2 MREG PAX6 PBX4 PICK1 PINX1 RASSF10 RBAK RBM48 SDCBP SDCBP2 STAT1 STX11 TBC1D5 TEPSIN TLE5 TNNI1 ZBTB14 ZBTB8A ZNF280A ZNF521 ZNF558
Entrez ID		55686	84285
HPRD ID		07645	14411
Ensembl ID		ENSG00000118242	ENSG00000175376
Uniprot IDs		Q8N565	Q8N9N8
PDB IDs			2DGY 6ZXF 6ZXG 6ZXH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding MRNA Processing RNA Binding Nucleic Acid Binding MRNA Metabolic Process Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization MRNA Alternative Polyadenylation Cellular Response To Oxygen-glucose Deprivation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of RNA Splicing RNA Processing MRNA Cleavage Factor Complex Response To Iron(II) Ion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Binding Cellular Response To Nitrogen Starvation Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Response To Oxygen-glucose Deprivation Autolysosome Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Phosphatidylethanolamine Binding Cellular Response To Forskolin Protein Heterotetramerization Response To Forskolin MRNA Cleavage And Polyadenylation Specificity Factor Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Response To Lead Ion Ribonucleoprotein Complex	Regulation Of Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis AP-2 Adaptor Complex Protein Binding
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