PIP4P2 and MMP16

		PIP4P2	MMP16
Description		phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2	matrix metallopeptidase 16
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix
	Molecular Function	Protein Binding Hydrolase Activity Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity	Metalloendopeptidase Activity Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Dephosphorylation Negative Regulation Of Phagocytosis	Skeletal System Development Ossification Endochondral Ossification Proteolysis Protein Processing Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Embryonic Cranial Skeleton Morphogenesis Bone Development Craniofacial Suture Morphogenesis
Pathways			Activation of Matrix Metalloproteinases TGFBR3 PTM regulation
Drugs			Marimastat Batimastat
Diseases
GWAS			A body shape index ( 34021172) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 21926974 28991256 25056061 23974872 22688191) Sweet taste perception in obesity with metabolic syndrome ( 31005965) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: GTF2IRD1 ITCH MMP16 NEDD4 NEDD4L RIPPLY3 SLC10A6 TNF TSG101 YAP1 ZFYVE27	5 interacting genes: DECR1 DNAAF5 KISS1 LRP1 PIP4P2
Entrez ID		55529	4325
HPRD ID		13233	03776
Ensembl ID		ENSG00000155099	ENSG00000156103
Uniprot IDs		Q8N4L2	P51512
PDB IDs			1RM8
Enriched GO Terms of Interacting Partners?		Sodium Channel Inhibitor Activity Receptor Internalization Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Cell Growth Potassium Channel Inhibitor Activity Regulation Of Growth Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Cell Population Proliferation Proline-rich Region Binding Negative Regulation Of DNA-templated Transcription Receptor Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Viral Budding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Potassium Ion Transport Cellular Response To Radiation Negative Regulation Of Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Receptor-mediated Endocytosis Positive Regulation Of Cell Growth Positive Regulation Of Developmental Growth Sodium Ion Transport Plasma Membrane Neuromuscular Junction Development Regulation Of Cellular Component Organization Regulation Of Protein Localization To Cell Surface Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Intracellular Receptor Signaling Pathway Multivesicular Body Receptor Metabolic Process Catabolic Process Proteolysis Protein Polyubiquitination Regulation Of Plasma Membrane Bounded Cell Projection Organization Vesicle-mediated Transport Mesenchyme Development Negative Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process	Kisspeptin Receptor Binding Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity 2,4-dienoyl-CoA Reductase (NADPH) Activity Lipid Modification Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Positive Regulation Of Luteinizing Hormone Secretion Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Lysosomal Protein Catabolic Process Lipid Metabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Regulation Of Endocytosis NADPH Binding Lipoprotein Transport Lysosomal Membrane Plasma Membrane Protein Complex Astrocyte Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Dynein Axonemal Particle Inner Dynein Arm Assembly Transcytosis Outer Dynein Arm Assembly Regulation Of Amyloid-beta Clearance Catalytic Complex Regulation Of Transport Cargo Receptor Activity Aorta Morphogenesis Regulation Of Extracellular Matrix Disassembly Amyloid-beta Metabolic Process Scavenger Receptor Activity Apoptotic Cell Clearance Phosphatidylinositol Dephosphorylation Negative Regulation Of Phagocytosis Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process
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