PRCC and TOE1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		PRCC	TOE1
Description		proline rich mitotic checkpoint control factor	target of EGR1, exonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding Zinc Ion Binding SnRNA Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Cycle	RNA Metabolic Process SnRNA 3'-end Processing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases		Renal cell carcinoma
GWAS		Sjögren's syndrome ( 28076899)
Interacting Genes		8 interacting genes: CSNK2A1 EGFR HOMER3 MAD2L2 PPIL2 RBM10 SRSF2 TOE1	27 interacting genes: ABCF3 AGGF1 ANXA1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 OGT PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		5546	114034
HPRD ID		01562	18212
Ensembl ID		ENSG00000143294	ENSG00000132773
Uniprot IDs		A0A0S2Z456 Q92733 Q96FT4	B4DP23 Q96GM8
PDB IDs			2FC6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process MRNA Metabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of DNA Repair RNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Negative Regulation Of Macromolecule Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Metabolic Process Multivesicular Body, Internal Vesicle Lumen RNA Processing RNA Splicing Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Regulation Of Cell Growth Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Speck MRNA Processing Regulation Of Cell Cycle Phase Transition Shc-EGFR Complex PML Body Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Regulation Of MRNA Splicing, Via Spliceosome Smooth Muscle Cell Apoptotic Process G Protein-coupled Glutamate Receptor Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Chromosome Segregation Negative Regulation Of Biosynthetic Process Positive Regulation Of DNA Repair Epidermal Growth Factor Binding Regulation Of MRNA Processing Nucleic Acid Binding Negative Regulation Of Ribosome Biogenesis	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Spliceosomal Complex MRNA Processing MRNA Metabolic Process Catalytic Step 2 Spliceosome RNA Metabolic Process Nucleoplasm Nuclear Speck Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Macromolecule Metabolic Process U2-type Precatalytic Spliceosome Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Regulation Of MRNA Processing Glutamatergic Synapse Cadherin Binding Involved In Cell-cell Adhesion RNA Binding Transition Metal Ion Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Membraneless Organelle Assembly U2-type Spliceosomal Complex Regulation Of Programmed Cell Death Alpha-2B Adrenergic Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Synaptic Vesicle Priming Oocyte Axis Specification
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