STRADB and PPIL3

		STRADB	PPIL3
Description		STE20 related adaptor beta	peptidylprolyl isomerase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Aggresome Serine/threonine Protein Kinase Complex	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity
	Biological Process	Cell Morphogenesis Protein Phosphorylation Protein Export From Nucleus JNK Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing
Pathways		Energy dependent regulation of mTOR by LKB1-AMPK	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		11 interacting genes: CAB39 COQ10B GRB2 MAP3K7 NEB PPIL3 SF3B1 STK11 TRAF6 UBC XIAP	20 interacting genes: ALS2 CDK11B CENATAC DMRTB1 MAIP1 MOB4 NOP58 NUP107 PCBP1 PHC1 RPS13 SHARPIN SLU7 SPATS2L SRPK1 STRADB TAB2 TAB3 WDR12 YTHDF1
Entrez ID		55437	53938
HPRD ID		09546	15163
Ensembl ID		ENSG00000082146	ENSG00000240344
Uniprot IDs		Q9C0K7	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs			1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Binding Immune Response-activating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical NF-kappaB Signal Transduction Interleukin-17A-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Anoikis Positive Regulation Of JUN Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway T Cell Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Modification Process DNA Damage Response Regulation Of Type I Interferon Production Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Serine/threonine Protein Kinase Complex Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway P38MAPK Cascade Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Cellular Response To Stress Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Activation Of Innate Immune Response Activation Of Protein Kinase Activity Regulation Of T Cell Cytokine Production Protein Kinase Activator Activity Toll-like Receptor 4 Signaling Pathway
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