WDR33 and NEK9

		WDR33	NEK9
Description		WD repeat domain 33	NIMA related kinase 9
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GO Annotations	Cellular Component	Fibrillar Center Collagen Trimer Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Cytoplasm Centrosome Cytosol
	Molecular Function	RNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Postreplication Repair MRNA Processing Spermatogenesis MRNA 3'-end Processing	Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) White blood cell count ( 32888494)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		20 interacting genes: CDK4 EEF1G GIT1 KAT7 MIR19A MIR19B1 MIR34B MIR92A2 NEK9 PFN2 PRMT1 RBM48 SH3GL3 TGFBR1 TP53 UBC UTP14A WWOX ZBTB16 ZHX1	25 interacting genes: BICD2 CSN2 GABARAP GZMB IFT43 JDP2 LIN52 MALL MAP1LC3A MAP1LC3B MBP NEK6 NEK7 NEK8 PALS1 PELI2 RAN RARG RPS6KL1 SSRP1 SUPT16H TTN UBC WDR33 WEE2-AS1
Entrez ID		55339	91754
HPRD ID		11680	11386
Ensembl ID		ENSG00000136709	ENSG00000119638
Uniprot IDs		Q9C0J8	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		6BLY 6BM0 6DNH 6F9N 6FUW 6URG 6URO 8E3I 8E3Q 8R8R	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Regulation Of Extracellular Matrix Assembly Response To Actinomycin D Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Post-transcriptional Gene Silencing Negative Regulation Of Matrix Metallopeptidase Secretion Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Differentiation Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Developmental Process Regulation Of Extracellular Matrix Organization Regulation Of Heart Growth Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly Cellular Response To Bacterial Lipopeptide Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cell Growth Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Regulation Of Cell Cycle Regulation Of Stem Cell Proliferation RISC Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Organ Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression MRNA Destabilization Regulation Of Cell Differentiation RNA Destabilization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial To Mesenchymal Transition	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly FACT Complex Organelle Assembly Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagosome Membrane Mitophagy Structural Constituent Of Myelin Sheath Microtubule Protein Serine Kinase Activity Autophagy Of Mitochondrion Autophagosome Protein Serine/threonine Kinase Activity Cellular Component Assembly Autophagosome Assembly Nucleosome Disassembly Microtubule Cytoskeleton Organization Protein-DNA Complex Disassembly Autophagosome Organization Endomembrane System Protein-containing Complex Organization Protein Kinase Activity Phospholipid Binding Cytoskeleton Microtubule-based Process Nucleosome Binding Positive Regulation Of Metalloendopeptidase Activity Protein Localization To Myelin Sheath Abaxonal Region DRM Complex Macroautophagy Spindle Organization Kinase Activity Pyroptotic Inflammatory Response Organelle Membrane Vacuole Organization
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