SYNJ2BP and CPLX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYNJ2BP	CPLX4
Description		synaptojanin 2 binding protein	complexin 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Plasma Membrane Membrane SNARE Complex Terminal Bouton Synapse
	Molecular Function	Protein Binding	SNARE Binding Protein Binding Syntaxin Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Targeting Rho Protein Signal Transduction Regulation Of Notch Signaling Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Endocytosis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Sprouting Angiogenesis	Neurotransmitter Transport Exocytosis Visual Perception Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Blood pressure ( 24954895) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) LDL cholesterol ( 30275531) Motor coordination ( 34177493) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)
Interacting Genes		35 interacting genes: ACTB ACVR2A ACVR2B APP AQP6 CD79A CPLX4 CREB3L1 CYB561 EBP ELOVL5 ELOVL7 ERGIC3 FAM210B FCER1G LHFPL5 LRP1 LRP2 LRP8 MEDAG RALBP1 REEP4 RPS6KA1 SLC10A6 SLC7A8 SMOC1 SYNJ2 THEM5 TLCD4 TMEM101 TMEM14B TMEM242 UBQLN1 USHBP1 VANGL2	100 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BMP10 BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 IGFBP5 INSIG2 LHFPL5 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 SMIM1 SNCA STX3 STX8 SYNJ2BP TF TMEM107 TMEM120B TMEM128 TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM42 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1
Entrez ID		55333	339302
HPRD ID		15455	13091
Ensembl ID		ENSG00000213463	ENSG00000166569
Uniprot IDs		P57105	Q7Z7G2
PDB IDs		2ENO 2JIK 2JIN 7P73 7P74 7PC9 7R2M 7R2T 8AEL
Enriched GO Terms of Interacting Partners?		Membrane Receptor Complex Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Activin Receptor Activity, Type II Activin Receptor Activity Endocytosis Import Into Cell Astrocyte Activation Involved In Immune Response Cargo Receptor Activity Long-chain Fatty-acyl-CoA Metabolic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Positive Regulation Of Protein Catabolic Process In The Vacuole Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Protein Binding Activin Binding Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Apical Protein Localization Response To Growth Factor Clathrin-coated Pit Vesicle-mediated Transport Plasma Membrane Protein Complex Receptor-mediated Endocytosis Retinoid Metabolic Process Regulation Of Developmental Process Gastrulation With Mouth Forming Second Heparan Sulfate Proteoglycan Binding Astrocyte Activation Transport Across Blood-brain Barrier Diterpenoid Metabolic Process Fatty Acid Derivative Metabolic Process Endoplasmic Reticulum Transcytosis Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Amyloid-beta Clearance Regulation Of Cell Differentiation Acyl-CoA Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Golgi Membrane Cholesterol Binding Intracellular Chemical Homeostasis Monoatomic Cation Homeostasis Pyrimidine Nucleotide-sugar Transmembrane Transport Monoatomic Ion Homeostasis Nucleotide-sugar Transmembrane Transport Homeostatic Process Vitamin K Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Golgi Apparatus Spindle Pole Centrosome Cellular Homeostasis Hydrogen Peroxide Channel Activity Negative Regulation Of Chaperone-mediated Autophagy Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Hydrogen Peroxide Transmembrane Transport Nuclear Inner Membrane Respiratory Burst After Phagocytosis Regulation Of Chemokine Production Negative Regulation Of Lipoprotein Metabolic Process Cellular Response To CAMP Zinc:proton Antiporter Activity Zinc Ion Transmembrane Transporter Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Zinc Ion Transmembrane Transport Menaquinone Metabolic Process Lysosome Zinc Ion Transport Glycerol Transmembrane Transport Multicellular Organismal-level Chemical Homeostasis Intracellular Zinc Ion Homeostasis Positive Regulation Of Chemokine Production Cortical Endoplasmic Reticulum Regulation Of Chaperone-mediated Autophagy Endomembrane System Long-chain Fatty Acid Catabolic Process Regulation Of Cellular Localization
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