PPP4C and PPP4R1

Number of citations of the paper that reports this interaction (PubMedID 18715871)
51

Data Source:
HPRD (in vitro, in vivo)

		PPP4C	PPP4R1
Description		protein phosphatase 4 catalytic subunit	protein phosphatase 4 regulatory subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Protein Phosphatase 4 Complex	Cytoplasm Protein Phosphatase 4 Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Protein Phosphorylation Signal Transduction
Pathways		Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)	Lean body mass ( 28552196) Metabolite levels ( 23823483) Platelet distribution width ( 27863252)
Interacting Genes		21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA TIPRL TK1 TMSB4X TP53 TRAF6 UBE2D3	6 interacting genes: CEP63 DISC1 DSCR9 HDAC3 PPP4C SASH1
Entrez ID		5531	9989
HPRD ID		03615	05366
Ensembl ID		ENSG00000149923	ENSG00000154845
Uniprot IDs		A0A024R625 P60510	Q8TF05
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Regulator Activity Tumor Necrosis Factor-mediated Signaling Pathway Protein Phosphatase 4 Complex Non-canonical NF-kappaB Signal Transduction General Transcription Initiation Factor Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process NF-kappaB P50/p65 Complex Protein Phosphatase Activator Activity Chromatin Response To Muscle Stretch Regulation Of MiRNA Metabolic Process Enzyme Binding NF-kappaB Complex DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Transcription Coactivator Binding Cellular Response To Nicotine Positive Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription Repressor Complex Regulation Of Interleukin-12 Production Meiotic Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Mechanical Stimulus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Response To Interleukin-1 Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Metabolic Process Actinin Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Protein Phosphatase Type 2A Complex Cytosol Transcription Regulator Complex Cytoplasm Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Chromatin Binding Transcription Cis-regulatory Region Binding	Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Polyubiquitination Molecular Adaptor Activity Regulation Of Protein K63-linked Ubiquitination Microtubule Cytoskeleton Organization Positive Regulation Of Ferroptosis Spindle Assembly Neural Precursor Cell Proliferation Centrosome Regulation Of Protein Modification Process Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Regulation Of Protein Metabolic Process Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Spindle Organization Protein Decrotonylase Activity Histone Decrotonylase Activity Organelle Assembly Protein Phosphatase 4 Complex Positive Regulation Of Protein Metabolic Process Cornified Envelope Assembly Microtubule-based Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Protein Autoubiquitination Radial Glia-guided Pyramidal Neuron Migration Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Phosphorylation Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Protein Polyubiquitination Positive Regulation Of Phosphorylation Cytoskeleton Organization Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Cardiac Muscle Cell Differentiation Cellular Response To Parathyroid Hormone Stimulus Membraneless Organelle Assembly Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
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