UEVLD and RNF114

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UEVLD	RNF114
Description		UEV and lactate/malate dehyrogenase domains	ring finger protein 114
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Cytoplasm Vesicle Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Catalytic Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Ubiquitin Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endosome To Lysosome Transport Protein Transport Carboxylic Acid Metabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Gut microbiota (beta diversity) ( 27723756) Inflammatory skin disease ( 25574825) Psoriasis ( 20953189 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 24871463)
Interacting Genes		7 interacting genes: DTX3 LRSAM1 RNF114 RNF4 SAAL1 TRAF6 UBC	29 interacting genes: AK5 BMI1 EVI2A HSPA5 MAP3K1 MAPK3 RNF38 RPSA SMURF1 TRAF4 TRAF6 TRAIP TRIM52 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2U UBE2W UEVLD
Entrez ID		55293	55905
HPRD ID		15608	10329
Ensembl ID		ENSG00000151116	ENSG00000124226
Uniprot IDs		B4DIA9 Q8IX04	Q9Y508
PDB IDs		2I6T 3DL2
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Autoubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Transferase Activity Zinc Ion Binding Macromolecule Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Kinetochore Assembly Modification-dependent Protein Catabolic Process Positive Regulation Of Synoviocyte Proliferation Regulation Of Centromere Complex Assembly SUMO Polymer Binding Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Localization To Chromatin Microtubule End Interleukin-17A-mediated Signaling Pathway Ubiquitin-dependent Endocytosis Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Transferase Activity Protein Modification Process Protein Metabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Macromolecule Metabolic Process Proteolysis Nucleotide Binding Ubiquitin Protein Ligase Activity Protein Monoubiquitination Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Regulation Of Protein Ubiquitination Nucleus Cytosol ISG15-protein Conjugation Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activator Activity TORC1 Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway DNA Damage Response Antiviral Innate Immune Response Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Signal Transduction TOR Signaling Ubiquitin-like Protein Transferase Activity
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