PPP2R5E and SGO1

Number of citations of the paper that reports this interaction (PubMedID 16541024)
0

Data Source:
HPRD (in vivo)

		PPP2R5E	SGO1
Description		protein phosphatase 2 regulatory subunit B'epsilon	shugoshin 1
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Protein Binding Kinase Binding
	Biological Process	Signal Transduction	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Schizophrenia ( 33169155) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)
Interacting Genes		24 interacting genes: APP BHLHE41 BTG3 BUB1B CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B CTNNA3 DELEC1 DOCK9 ENO1 FBXW11 GPRASP3 OGT PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9	23 interacting genes: CDCA8 ICOSLG LRRC59 POLE4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC PTPA RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6
Entrez ID		5529	151648
HPRD ID		09040	12377
Ensembl ID		ENSG00000154001	ENSG00000129810
Uniprot IDs		Q16537	B5BUA4 Q5FBB7
PDB IDs		8UWB	3FGA 3Q6S 4A0I 7ZJS
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Circadian Rhythm Photoperiodism Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Small Molecule Metabolic Process Nucleus Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Carbohydrate Catabolic Process Response To Lead Ion Positive Regulation Of Circadian Rhythm Regulation Of ATP Metabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock Positive Regulation Of Proteolysis Negative Regulation Of Signal Transduction Regulation Of Proteolysis Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Glucocorticoid Secretion Regulation Of Glucose Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Response To Radiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Sister Chromatid Cohesion Response To Blue Light Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Glycolytic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process E-box Binding Photoreceptor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity Meiotic Sister Chromatid Cohesion Chromosome Organization Cytosolic Large Ribosomal Subunit DNA-dependent Protein Kinase Complex Chromosome, Centromeric Region DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Cytosolic Ribosome Sister Chromatid Cohesion Cytosol Cytoplasmic Translation Nucleus Structural Constituent Of Ribosome FAR/SIN/STRIPAK Complex Chromosome DNA End Binding Ku70:Ku80 Complex Ribosome Small-subunit Processome Assembly Cytoplasm Ribonucleoprotein Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein-DNA Complex 5'-deoxyribose-5-phosphate Lyase Activity Response To Gamma Radiation Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Macromolecule Biosynthetic Process Spindle Organization Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ribonucleoprotein Complex Biogenesis Translation U3 SnoRNA Binding Protein Serine/threonine Phosphatase Activity INTAC Complex Spindle Assembly Response To Lead Ion Telomere Maintenance RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Ribosome Biogenesis Hyperosmotic Response RNA Binding Maturation Of LSU-rRNA Telomeric DNA Binding Cellular Response To Gamma Radiation
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