UBE2W and MIB1

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2W	MIB1
Description		ubiquitin conjugating enzyme E2 W	MIB E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein Antiviral Innate Immune Response Negative Regulation Of TORC1 Signaling	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)	Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)
Interacting Genes		82 interacting genes: AKR1C3 AMFR ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED ELOC FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM3 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM7 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4	20 interacting genes: AZI2 BLM CABLES1 CHST9 DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 RMC1 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN
Entrez ID		55284	57534
HPRD ID		07724	06660
Ensembl ID		ENSG00000104343	ENSG00000101752
Uniprot IDs		Q96B02 Q96FI0 X6REH9	Q86YT6
PDB IDs		2A7L 2MT6 8A58	4TSE 4XI6 4XI7 4XIB 8V0D 8V0E
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Transferase Activity Zinc Ion Binding Protein Metabolic Process Metal Ion Binding Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Cytoplasm Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Catabolic Process Innate Immune Response Immune System Process DNA Damage Response Positive Regulation Of Autophagy Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Other Organism Regulation Of Autophagy Regulation Of Signaling Regulation Of Cell Communication Regulation Of Defense Response Defense Response To Symbiont Endoplasmic Reticulum Mannose Trimming Intracellular Signal Transduction Defense Response To Other Organism Response To External Biotic Stimulus	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination
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