PPP2R5C and FBLN5

		PPP2R5C	FBLN5
Description		protein phosphatase 2 regulatory subunit B'gamma	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Sister Chromatid Cohesion	Negative Regulation Of Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		23 interacting genes: APP ATM AXIN1 BRCA1 BUB1B CHEK2 CIP2A DYNC1H1 EP300 FBLN5 IER3 MAPK1 MBP OGT PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1	23 interacting genes: ATN1 COXFA4 GFI1B GSC HOXA1 LGMN LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		5527	10516
HPRD ID		03385	05204
Ensembl ID		ENSG00000078304	ENSG00000140092
Uniprot IDs		A0A8Q3WKR3 Q13362	A0A024R6G3 A0A9L9PXD9 G3V2P8 G3V4U0 G3XA98 Q9UBX5
PDB IDs		2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 7OUF 7OUG 7OUH 7PEL 7SOY
Enriched GO Terms of Interacting Partners?		Response To Radiation Regulation Of Carbohydrate Catabolic Process Intracellular Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Regulation Of Small Molecule Metabolic Process Cell Death Regulation Of Generation Of Precursor Metabolites And Energy DNA Damage Response Regulation Of ATP Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Purine Nucleotide Metabolic Process PTW/PP1 Phosphatase Complex Intrinsic Apoptotic Signaling Pathway Regulation Of Organelle Organization Chromosome Cellular Response To Stress Chromosome Organization Protein Modification Process Regulation Of Cellular Response To Stress Regulation Of Cellular Component Organization Cytosol Circadian Rhythm Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Regulation Of Intracellular Transport Regulation Of Cell Cycle Phase Transition Cell Division Signal Transduction In Response To DNA Damage RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Circadian Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Signaling Response To Lead Ion Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Radiation Positive Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Regulation Of Cell Cycle Process Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Localization Organelle Organization Phosphate-containing Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity	Copper Ion Binding Nuclear Matrix Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Heparin Binding Plasma Lipoprotein Particle Diencephalon Morphogenesis Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protease Binding Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Glycosaminoglycan Binding Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Type 8 Metabotropic Glutamate Receptor Binding Dendritic Spine Organization Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis RNA Topoisomerase Activity Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Negative Regulation Of Type II Interferon Production Postsynapse Organization
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