UBA6 and UBE2A

Number of citations of the paper that reports this interaction (PubMedID 37604583)
54

Data Source:
BioGRID (enzymatic study)

		UBA6	UBE2A
Description		ubiquitin like modifier activating enzyme 6	ubiquitin conjugating enzyme E2 A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleoplasm Lysosome Endosome Late Endosome Cytosol HULC Complex
	Molecular Function	Nucleotide Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity FAT10 Activating Enzyme Activity Metal Ion Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cytoplasmic Translation DNA Repair Postreplication Repair Chromatin Organization Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To UV Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Mitophagy
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Brain connectivity ( 23471985)
Interacting Genes		26 interacting genes: BIRC6 HMBOX1 HUWE1 JUNB LMO2 OTUB1 SMAD9 UBC UBD UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2O UBE2S UBE2T UBE2Z	32 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 H2BC3 HECTD3 HLTF KCMF1 MDM2 PCNA PRKN PSMG1 RAD18 RC3H1 RNF167 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBA6 UBC UBR1 UBR3 UBR5 ZMYM2
Entrez ID		55236	7319
HPRD ID		13341	02422
Ensembl ID		ENSG00000033178	ENSG00000077721
Uniprot IDs		A0AVT1	A0A0D9SG71 P49459
PDB IDs		7PVN 7PYV 7SOL	6CYO 6CYR 8BTL 8IEJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Macromolecule Catabolic Process Proteolysis Transferase Activity Protein Metabolic Process Protein Monoubiquitination ATP Binding Protein K63-linked Ubiquitination Nucleoplasm Catabolic Process Nucleotide Binding Macromolecule Metabolic Process ISG15 Transferase Activity Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein K29-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Cytosol Protein Autoubiquitination Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion HULC Complex Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Free Ubiquitin Chain Polymerization DNA Metabolic Process DNA Repair Cell Cycle Phase Transition	Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Cellular Response To Stress Macromolecule Catabolic Process Transferase Activity DNA Damage Response Proteolysis Catabolic Process Chromatin Organization Protein K63-linked Ubiquitination Macromolecule Metabolic Process Response To Stress Nucleoplasm PML Body Zinc Ion Binding Ubiquitin Protein Ligase Binding Chromatin Remodeling Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K29-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Transcription By RNA Polymerase II Proteasomal Protein Catabolic Process Nucleus DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Hydrogen Peroxide Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription P53 Binding Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Activity Cellular Response To Actinomycin D Ubiquitin Activating Enzyme Activity Negative Regulation Of DNA-templated Transcription
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