RPRD1A and RIOK2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPRD1A	RIOK2
Description		regulation of nuclear pre-mRNA domain containing 1A	RIO kinase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Preinitiation Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Identical Protein Binding RNA Polymerase II C-terminal Domain Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	RNA Polymerase II Promoter Clearance MRNA 3'-end Processing	Regulation Of Mitotic Metaphase/anaphase Transition Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Protein Autophosphorylation Positive Regulation Of Ribosomal Small Subunit Export From Nucleus Positive Regulation Of RRNA Processing
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs			Fostamatinib
Diseases
GWAS		Drug-induced torsades de pointes ( 24223155) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Chronic mountain sickness ( 31417607) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: BCAR3 FAM90A1 HGS KDM1A KPNA3 LONRF1 NXF1 PCNT RIOK2 SDCBP YWHAZ ZNF410 ZNF76	7 interacting genes: APP CSNK2A1 GFUS PRDM16 RELA RPRD1A SMAD3
Entrez ID		55197	55781
HPRD ID		10134	10193
Ensembl ID		ENSG00000141425	ENSG00000058729
Uniprot IDs		A0A0C4DGQ6 Q96P16	Q9BVS4
PDB IDs		4JXT 4NAC	5DHF 6FDM 6FDN 6FDO 6G18 6G51 6HK6 7VBT 7WU0 9F81
Enriched GO Terms of Interacting Partners?		Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion	Negative Regulation Of MiRNA Transcription Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Protein Catabolic Process Identical Protein Binding Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Negative Regulation Of Protein Catabolic Process DNA-binding Transcription Factor Binding Response To Angiotensin Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Metabolic Process Transcription Cis-regulatory Region Binding Cellular Response To Growth Factor Stimulus Regulation Of Amyloid Precursor Protein Catabolic Process Transcription Coactivator Binding Regulation Of Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of MiRNA Transcription Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Catabolic Process Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Lung Blood Pressure Positive Regulation Of MiRNA Metabolic Process Nuclear Mineralocorticoid Receptor Binding GDP-L-fucose Synthase Activity GDP-4-dehydro-D-rhamnose Reductase Activity GDP-mannose 3,5-epimerase Activity Regulation Of Inflammatory Response Response To Interleukin-1 DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA Binding Response To CAMP Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process
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