CEP55 and LRRC23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP55	LRRC23
Description		centrosomal protein 55	leucine rich repeat containing 23
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body	Cytoplasm Cytosol Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development	Flagellated Sperm Motility Radial Spoke Assembly
Pathways
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)	Lung function (FEV1/FVC) ( 30175238) Refractive error ( 32231278)
Interacting Genes		94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48	2 interacting genes: CD28 CEP55
Entrez ID		55165	10233
HPRD ID		12569	09818
Ensembl ID		ENSG00000138180	ENSG00000010626
Uniprot IDs		Q53EZ4	A8K8K2 Q53EV4
PDB IDs		3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly	Positive Regulation Of Interleukin-10 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Protein Complex Involved In Cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Interleukin-4 Production T Cell Costimulation Regulation Of Interleukin-4 Production Thymic T Cell Selection Positive Regulation Of Isotype Switching Immunological Synapse Regulation Of Regulatory T Cell Differentiation Alpha-beta T Cell Proliferation Regulatory T Cell Differentiation Negative Thymic T Cell Selection Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative T Cell Selection Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation T Cell Selection Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Production Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Alpha-beta T Cell Proliferation Mitotic Cytokinetic Process Flemming Body Midbody Abscission Cytokinetic Process Cranial Skeletal System Development Mitotic Metaphase Chromosome Alignment Positive Regulation Of Immunoglobulin Production Coreceptor Activity CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Viral Process Metaphase Chromosome Alignment Cleavage Furrow Regulation Of Interleukin-2 Production Regulation Of Interleukin-10 Production Mitotic Cytokinesis Positive Regulation Of DNA Recombination Regulation Of Viral Genome Replication T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Immunoglobulin Production Chromosome Localization Regulation Of CD4-positive, Alpha-beta T Cell Activation
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