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PPP2CA and PPP1CA
Number of citations of the paper that reports this interaction (PubMedID
12370081
)
36
Data Source:
HPRD
(in vitro, in vivo)
PPP2CA
PPP1CA
Description
protein phosphatase 2 catalytic subunit alpha
protein phosphatase 1 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Spindle Pole
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Protein Serine/threonine Phosphatase Complex
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
INTAC Complex
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Neuronal Cell Body
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Postsynapse
Glutamatergic Synapse
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Iron Ion Binding
Protein Binding
Protein Phosphatase 1 Binding
Hydrolase Activity
Phosphatase Activity
Ribonucleoprotein Complex Binding
Protein-containing Complex Binding
Metal Ion Binding
Transition Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
Biological Process
Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Mesoderm Development
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Polymerization
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
RNA Polymerase II Transcription Initiation Surveillance
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
RNA Polymerase II Promoter Clearance
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Response To Lead Ion
Dephosphorylation
Lung Development
Circadian Regulation Of Gene Expression
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Telomere Maintenance In Response To DNA Damage
Regulation Of Translational Initiation In Response To Stress
Positive Regulation Of Glycogen Biosynthetic Process
Branching Morphogenesis Of An Epithelial Tube
Protein Stabilization
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Cell-cell Adhesion
Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Maturation of hRSV A proteins
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Interacting Genes
102 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
IL3
ISYNA1
JAK2
KISS1R
L3MBTL3
MAP4K1
MAP4K3
MAP4K4
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
POLR2A
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
UBC
VAC14
VDR
XRN1
YPEL3
175 interacting genes:
AATK
AHCTF1
AKAP1
AKAP11
AKAP9
AKT1
APAF1
ASPM
ATP5MG
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDCA2
CDH1
CEP126
CEP170
CEP192
CKB
CLCN2
CLOCK
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
ITGB8
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MECOM
MIIP
MKI67
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEDD8
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PBK
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHB2
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RELA
RORC
RPRD2
RRP1B
SAXO4
SEH1L
SFI1
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TRIM21
TSC2
TUSC3
UBC
UBE2Z
UBR5
ULK1
VDR
WBP11
WDR82
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
Entrez ID
5515
5499
HPRD ID
08912
15942
Ensembl ID
ENSG00000113575
ENSG00000172531
Uniprot IDs
B3KQ51
B3KUN1
P67775
A0A140VJS9
P62136
PDB IDs
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
4NY3
5W0W
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
6ZK6
7QFB
7QM2
7T0Y
7TVF
7TXH
7UPI
8DWK
8DWL
8SW5
8SW6
8U5G
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Intracellular Signal Transduction
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Cytosol
Regulation Of Cell Population Proliferation
Protein Phosphatase Regulator Activity
Protein Phosphorylation
Protein Phosphatase Type 2A Complex
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Apoptotic Process
Regulation Of Cell Cycle
Programmed Cell Death
Cell Death
Protein Phosphatase 2A Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cytoplasm
Nucleus
Response To Ketone
Response To Lipid
Regulation Of Mitotic Cell Cycle
Response To Starvation
Positive Regulation Of Intracellular Signal Transduction
Protein Modification Process
Regulation Of Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Identical Protein Binding
Positive Regulation Of Apoptotic Process
Cellular Response To Stress
Protein Metabolic Process
Response To Nutrient Levels
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Protein Phosphatase 1 Binding
Protein Phosphatase Inhibitor Activity
Phosphatase Binding
Intracellular Signal Transduction
Protein Phosphatase Regulator Activity
Protein Phosphatase Type 1 Complex
Negative Regulation Of Intracellular Signal Transduction
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Cell Cycle
Enzyme Binding
Regulation Of Intracellular Signal Transduction
Nucleoplasm
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Intrinsic Apoptotic Signaling Pathway
Nucleus
Glycogen Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Glycogen Binding
Regulation Of Cell Cycle Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Cytoplasm
Positive Regulation Of Metabolic Process
Polysaccharide Metabolic Process
Energy Reserve Metabolic Process
Cell Population Proliferation
Release Of Cytochrome C From Mitochondria
Chromosome
Response To Radiation
Apoptotic Signaling Pathway
Negative Regulation Of Metabolic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Programmed Cell Death
Response To Starvation
Regulation Of Glycogen Biosynthetic Process
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Protein Metabolic Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Response To Light Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Bcl-2 Family Protein Complex
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Tagcloud (Difference)
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Tagcloud (Intersection)
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