PLEKHJ1 and PHETA1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		PLEKHJ1	PHETA1
Description		pleckstrin homology domain containing J1	PH domain containing endocytic trafficking adaptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Trans-Golgi Network Cytosol Recycling Endosome	Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	Protein Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways
Drugs
Diseases
GWAS		Pulse pressure ( 26390057) Waist-hip index ( 34021172)
Interacting Genes		10 interacting genes: ACVR1 APP DNMT3B IKBKG LAGE3 NTAQ1 PHETA1 PIH1D2 PPBP TGFBR1	14 interacting genes: ABI2 C11orf68 CYSRT1 FCHO1 GRB2 HOXA1 KRTAP1-3 KRTAP13-2 KRTAP6-3 NCK2 OIP5 PLEKHJ1 SNCA SORBS3
Entrez ID		55111	144717
HPRD ID		15150	08127
Ensembl ID		ENSG00000104886	ENSG00000198324
Uniprot IDs		K7EIZ3 Q9NW61	Q8N4B1
PDB IDs			3QIS
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Apoptotic Signaling Pathway Pharyngeal System Development Platelet Alpha Granule Transforming Growth Factor Beta Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Growth Factor Binding Cellular Response To Growth Factor Stimulus Endocardial Cushion Cell Fate Commitment Protein Homodimerization Activity SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Bacterium DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Protein-N-terminal Glutamine Amidohydrolase Activity Platelet Alpha Granule Lumen Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein-N-terminal Asparagine Amidohydrolase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Positive Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Cytoskeletal Anchor Activity Regulation Of Actin Filament-based Process Intermediate Filament Receptor-mediated Endocytosis Vesicle Membrane Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Actin Filament Polymerization Semicircular Canal Formation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Cellular Component Organization Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Grb2-EGFR Complex Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Zonula Adherens Assembly Identical Protein Binding ERBB Signaling Pathway Regulation Of Organelle Organization Signaling Adaptor Activity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Protein Polymerization Cytosol Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Pericentric Heterochromatin Organization CENP-A Recruiting Complex
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