PPP1R8 and RTN4IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPP1R8	RTN4IP1
Description		protein phosphatase 1 regulatory subunit 8	reticulon 4 interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Membrane
	Molecular Function	DNA Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity Hydrolase Activity Protein Phosphatase Regulator Activity Molecular Function Inhibitor Activity	Nucleotide Binding Protein Binding Zinc Ion Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity
	Biological Process	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing	Ubiquinone Biosynthetic Process Nervous System Development Regulation Of Dendrite Development
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: APP APPBP2 CDC5L CNKSR1 CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77	23 interacting genes: ARFGAP3 CALCOCO2 CBFA2T3 CENPK CTAG1A CTAG1B ERMN EXOC7 GGA2 HDX MARCHF5 PPP1R8 PYM1 RELA RTN4 RTN4R RUNX1T1 SCAF1 SMURF2 SORBS1 WBP11 WWTR1 ZYX
Entrez ID		5511	84816
HPRD ID		04028	18008
Ensembl ID		ENSG00000117751	ENSG00000130347
Uniprot IDs		Q12972 Q6ICT4	Q8WWV3
PDB IDs		3V4Y	2VN8
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Nucleoplasm Postsynapse Cellular Response To Catecholamine Stimulus Response To Catecholamine Protein Modification Process Protein Kinase CK2 Complex Intracellular Signal Transduction Protein Metabolic Process Spliceosomal Complex Cellular Response To Stress Regulation Of Proteolysis Enzyme Binding MRNA Metabolic Process Rhythmic Process Cellular Response To Dopamine PTW/PP1 Phosphatase Complex Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Signaling Receptor Activator Activity Nucleobase-containing Compound Metabolic Process MRNA Processing Response To Dopamine Cellular Response To Heat Perikaryon Cellular Response To Manganese Ion Chromatin Binding Protein Kinase Activity DNA Repair Positive Regulation Of Gliogenesis Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Circadian Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Programmed Cell Death Nucleus Response To Manganese Ion Prp19 Complex Protein Serine Kinase Activity Golgi-associated Vesicle Chromatin Organization Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process RNA Splicing MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy ESC/E(Z) Complex Negative Regulation Of Gene Expression	RNA Metabolic Process
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