ENOX1 and AKAP11

		ENOX1	AKAP11
Description		ecto-NOX disulfide-thiol exchanger 1	A-kinase anchoring protein 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Disulfide Isomerase Activity NADH Dehydrogenase Activity Protein Binding Oxidoreductase Activity	Protein Binding Protein Phosphatase 1 Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Ultradian Rhythm Rhythmic Process	Renal Water Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Protein Localization Cortical Actin Cytoskeleton Organization Intracellular Signal Transduction Protein Localization To Endosome
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) End-stage coagulation ( 23381943) Major depressive disorder ( 23377640) Mercury levels ( 26025379) Parent of origin effect on receptive language ability (paternal) ( 32635940) Photic sneeze reflex ( 27182965) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309) Response to tocilizumab in rheumatoid arthritis ( 22491018) Schizophrenia ( 33169155)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740) Bone mineral density (spine) ( 19801982) Crohn's disease ( 28067908) Hepcidin levels ( 27846281) Inflammatory bowel disease ( 28067908) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Serum alkaline phosphatase levels ( 33339817 33547301) Type 1 diabetes ( 34012112 34127860)
Interacting Genes		14 interacting genes: AKAP11 EEF1G EIF6 ENOX2 GORASP2 LNX1 NAA16 NIF3L1 SDCBP SMIM2 SULT1E1 TRIM43 ZBTB16 ZMYND19	9 interacting genes: ENOX1 GSK3A GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B WEE2-AS1
Entrez ID		55068	11215
HPRD ID		07644	05261
Ensembl ID		ENSG00000120658	ENSG00000023516
Uniprot IDs		A0A024RDT8 A0A0S2Z5N4 Q8TC92	Q9UKA4
PDB IDs
Enriched GO Terms of Interacting Partners?			Protein Kinase A Catalytic Subunit Binding CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Postsynapse CAMP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Metabolic Process Ciliary Base Regulation Of Glycogen (starch) Synthase Activity Regulation Of CAMP/PKA Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Protein Domain Specific Binding Glutamatergic Synapse Cellular Response To Interleukin-3 PTW/PP1 Phosphatase Complex Rhythmic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Beta-catenin Destruction Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Carbohydrate Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Tau-protein Kinase Activity Dendritic Spine Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Phosphatase 1 Binding Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Membrane Permeability Plasma Membrane Raft Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Presynapse
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