ZWILCH and ZW10

Number of citations of the paper that reports this interaction (PubMedID 12686595)
45

Data Source:
HPRD (in vitro, in vivo)

		ZWILCH	ZW10
Description		zwilch kinetochore protein	zw10 kinetochore protein
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Kinetochore Microtubule Cytosol RZZ Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Spindle Kinetochore Microtubule Cytosol Cytoskeleton Membrane Dsl1/NZR Complex RZZ Complex
	Molecular Function	Protein Binding	Protein Binding Centromeric DNA Binding
	Biological Process	Mitotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Mitotic Metaphase Chromosome Alignment Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Exit From Mitosis Protein Transport Vesicle-mediated Transport Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body mass index ( 29273807)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Parental longevity (father's attained age) ( 29227965)
Interacting Genes		3 interacting genes: KNTC1 UBC ZW10	8 interacting genes: APP CEBPA DCTN2 PIAS4 PTF1A RINT1 ZWILCH ZWINT
Entrez ID		55055	9183
HPRD ID		07640	04902
Ensembl ID		ENSG00000174442	ENSG00000086827
Uniprot IDs		A8K4T3 Q9H900	O43264
PDB IDs		3IF8 7QPG	7QPG
Enriched GO Terms of Interacting Partners?		RZZ Complex Protein Localization To Kinetochore Regulation Of Exit From Mitosis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Mitotic Sister Chromatid Segregation Negative Regulation Of Mitotic Metaphase/anaphase Transition Kinetochore Microtubule Negative Regulation Of Mitotic Nuclear Division Protein Localization To Chromosome, Centromeric Region Sister Chromatid Segregation Nuclear Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Protein Localization To Kinetochore Involved In Kinetochore Assembly Chromosome Segregation Regulation Of Nuclear Division Spindle Pole Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinetochore Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Dsl1/NZR Complex Spindle Regulation Of Chromosome Organization Negative Regulation Of Cell Cycle Process Centromeric DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Division Protein Tag Activity Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Mitotic Metaphase Chromosome Alignment Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum	Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Negative Regulation Of Chromosome Organization Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Phase Transition Homologous Chromosome Orientation In Meiotic Metaphase I Limb Epidermis Development PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division
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