C14orf119 and RND3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C14orf119	RND3
Description		chromosome 14 open reading frame 119	Rho family GTPase 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process		Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways			RND3 GTPase cycle
Drugs			Guanosine-5'-Triphosphate
Diseases
GWAS			Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Daytime nap ( 33568662) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		56 interacting genes: ACTN4 ARID3C ARID5A AUNIP BEND7 BIN3 C1QTNF1 CCND3 CDC14A CHMP1A CLPP CTAG1A CTAG1B DDIT4L DECR2 DYNLL1 DYNLL2 HES6 HLX HMG20B ITGB3BP KHDC4 KRT4 KRT78 KRTAP13-3 LASP1 LDB2 LENG1 LRRCC1 MEOX1 MORN3 MYF5 NIF3L1 NME4 NRIP3 NUP54 NUP62 PBX4 PHACTR1 PINX1 RAB3IL1 REL RHOU RND3 RNF4 RPIA SMCP SNX8 SSX4 SSX4B STN1 SYCP3 TEX35 TLE5 UBXN11 WASHC1	11 interacting genes: ARHGAP5 C14orf119 CDH5 CFTR CIT CPLANE2 GCH1 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		55017	390
HPRD ID		16595	04233
Ensembl ID		ENSG00000179933	ENSG00000115963
Uniprot IDs		Q9NWQ9	B2R838 P61587
PDB IDs			1M7B 2V55 4BG6 7OBC 7OBD 8B2K 8BFC
Enriched GO Terms of Interacting Partners?		Protein Binding	Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Communication Regulation Of Signaling Epithelial Cell Migration Regulation Of Endothelial Cell Differentiation Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding GTP Cyclohydrolase I Activity Rho Protein Signal Transduction Mitotic Cytokinesis GTPase Activity Regulation Of Signal Transduction Positive Regulation Of Anion Channel Activity PDZ Domain Binding Rho-dependent Protein Serine/threonine Kinase Activity Cell Migration Cell Adhesion Membrane Docking Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Nitric-oxide Synthase Activity Cytoskeleton-dependent Cytokinesis Regulation Of Cell Motility Ameboidal-type Cell Migration Regulation Of Locomotion Regulation Of Biological Quality Cell Motility Regulation Of Cell Migration Positive Regulation Of Establishment Of Endothelial Barrier Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Blood Vessel Maturation Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Fibrinogen Binding Regulation Of Epithelial Cell Differentiation Nucleotide Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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