FAM118A and WDR4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM118A	WDR4
Description		family with sequence similarity 118 member A	WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Enzyme Activator Activity TRNA Methyltransferase Activator Activity
	Biological Process		TRNA Modification DNA Damage Response TRNA Processing RNA (guanine-N7)-methylation TRNA Stabilization TRNA (guanine-N7)-methylation
Pathways			tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Colon cancer ( 33632709) Dentures ( 31235808) Distal colorectal cancer ( 33632709) Heel bone mineral density ( 30598549) Height ( 31562340) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Peanut allergy (maternal genetic effects) ( 29489655) Periventricular white matter hyperintensities ( 32517579)	Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)
Interacting Genes		14 interacting genes: AIDA ATOX1 CDC37 DCDC2 FAM118B GLRX3 LNX1 MOB1A MOB3C RNF4 SDCBP UBE2I WDR4 ZNF451	18 interacting genes: CADPS2 CAPZA2 CDC42BPB COPS5 FAM118A FEN1 HLA-DRA METTL1 PAX6 PTPN23 RABGGTB REV3L SF3B4 TERF1 TERF2 UBE3A ZMYND8 ZNF84
Entrez ID		55007	10785
HPRD ID		07936	09330
Ensembl ID		ENSG00000100376	ENSG00000160193
Uniprot IDs		Q9NWS6	P57081
PDB IDs			7U20 8CTH 8CTI 8D58 8D9K 8D9L 8EG0 8H0N
Enriched GO Terms of Interacting Partners?		PML Body	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping DNA Biosynthetic Process Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization RNA-templated DNA Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process Nucleoplasm DNA Metabolic Process Chromosome, Telomeric Region Internal MRNA (guanine-N7-)-methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Homophilic Cell Adhesion Organelle Localization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Double-stranded DNA Exodeoxyribonuclease Activity Regulation Of Chromosome Organization Flap Endonuclease Activity DNA Recombination
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