TMEM161A and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TMEM161A	PTGER4
Description		transmembrane protein 161A	prostaglandin E receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Response To Retinoic Acid Cellular Response To Oxidative Stress Cellular Response To UV Positive Regulation Of DNA Repair Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways			Prostanoid ligand receptors G alpha (s) signalling events
Drugs			Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		13 interacting genes: AGTR1 CCR2 CHRM5 F2RL1 GATAD2A GNRHR GPR35 GPR37 NR1H2 NR1H3 OXTR PTGER4 SLC22A2	43 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TCHH TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		54929	5734
HPRD ID		07905	03350
Ensembl ID		ENSG00000064545	ENSG00000171522
Uniprot IDs		K7EPA3 Q9NX61	A0PJF5 P35408
PDB IDs			5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Regulation Of Body Fluid Levels Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Pinocytosis Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Transport Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Regulation Of Defense Response Negative Regulation Of Cholesterol Storage Vascular Process In Circulatory System Regulation Of System Process Regulation Of Secretion By Cell Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Secretion Circulatory System Process Regulation Of Lipid Metabolic Process Regulation Of Triglyceride Biosynthetic Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Dopamine Transport Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Chemokine Receptor Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Apoptotic Cell Clearance Positive Regulation Of Metabolic Process Negative Regulation Of Secretion By Cell Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Regulation Of Tube Size Plasma Membrane Positive Regulation Of Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process	Heme Oxidation Heme Oxygenase (decyclizing) Activity
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