LIME1 and TMEM74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LIME1	TMEM74
Description		Lck interacting transmembrane adaptor 1	transmembrane protein 74
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane B Cell Receptor Complex	Autophagosome Membrane Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction	Autophagy Macroautophagy General Adaptation Syndrome, Behavioral Process
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 23128233 28067908) Lipoprotein (a) levels ( 33730874) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)	Male-pattern baldness ( 27182965)
Interacting Genes		46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1	7 interacting genes: AQP6 FATE1 LIME1 LMNA MS4A13 SPCS1 TMEM42
Entrez ID		54923	157753
HPRD ID		07904	08702
Ensembl ID		ENSG00000203896	ENSG00000164841
Uniprot IDs		A0A087WT39 Q9H400	Q96NL1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex B Cell Receptor Signaling Pathway Organelle Fusion Lysosome Ephrin Receptor Binding Regulation Of Cellular Localization Vesicle Organization Plasma Membrane Organelle Membrane Fusion Vesicle Fusion Protein Binding Phosphotyrosine Residue Binding T Cell Costimulation Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Syntaxin Binding Fc Receptor Signaling Pathway Golgi Apparatus Vesicle Docking Spindle Pole Centrosome Antigen Receptor-mediated Signaling Pathway Endomembrane System SNARE Binding Immune Response-regulating Signaling Pathway Membrane Fusion Vesicle-mediated Transport Activation Of Immune Response	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Signal Peptidase Complex B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Monoatomic Anion Channel Activity Renal Water Transport Negative Regulation Of Mesenchymal Cell Proliferation Virion Assembly Ammonium Channel Activity Signal Peptide Processing Ammonium Transmembrane Transport Ventricular Cardiac Muscle Cell Development
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