CWC25 and LAMC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CWC25	LAMC3
Description		CWC25 spliceosome associated protein	laminin subunit gamma 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Nuclear Speck U2-type Catalytic Step 1 Spliceosome	Extracellular Region Basement Membrane Membrane Extracellular Matrix
	Molecular Function	Protein Binding	Structural Molecule Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Cell Morphogenesis Cell Adhesion Visual Perception Astrocyte Development Retina Development In Camera-type Eye
Pathways		mRNA Splicing - Major Pathway	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998)	Alcohol consumption (max-drinks) ( 29460428) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Degraded stimulus continuous performance test score ( 31596458) Endometriosis ( 28333195) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 27749845) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		8 interacting genes: CCDC85B FMR1 GSDMB KRT34 LAMC3 MDM2 OGT TRIM21	20 interacting genes: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		54883	10319
HPRD ID		07892	05069
Ensembl ID		ENSG00000273559	ENSG00000050555
Uniprot IDs		Q9NXE8	Q8N2D6 Q9Y6N6
PDB IDs		5YZG 6ZYM 8I0W
Enriched GO Terms of Interacting Partners?		Pyroptotic Inflammatory Response Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Life Cycle Negative Regulation Of Protein Metabolic Process Stress Granule Assembly Cellular Response To Nutrient Negative Regulation Of Translational Initiation Membraneless Organelle Assembly Positive Regulation Of Viral Process Positive Regulation Of Intracellular Transport Of Viral Material Response To Formaldehyde Protein Autoubiquitination Cellular Response To Vitamin B1 Protein Destabilization Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Catabolic Process Regulation Of Receptor Internalization Regulation Of Proteolysis Cytoplasmic Stress Granule Negative Regulation Of Post-translational Protein Modification Dendritic Filopodium Histone H3 Reader Activity Cytotoxic T Cell Pyroptotic Cell Death Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Long-term Synaptic Depression Regulation Of Viral Life Cycle Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Translational Initiation Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Actinomycin D Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process NEDD8 Ligase Activity Response To Actinomycin D Negative Regulation Of Proteolysis Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Inflammatory Response Negative Regulation Of Protein Deubiquitination Response To Nutrient RNA Strand Annealing Activity Regulation Of Neuronal Action Potential	Acute-phase Response Blood Microparticle Acute Inflammatory Response Response To Bacterium Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage
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