TRIT1 and SHE

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		TRIT1	SHE
Description		tRNA isopentenyltransferase 1	Src homology 2 domain containing E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Metal Ion Binding TRNA Dimethylallyltransferase Activity	Phosphotyrosine Residue Binding Protein Binding
	Biological Process	TRNA Modification TRNA Processing Mitochondrial TRNA Modification
Pathways		tRNA modification in the nucleus and cytosol tRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798)
Interacting Genes		7 interacting genes: AKT1 ANKS1A COL6A3 HGH1 OGT SHE SMYD3	6 interacting genes: ABL1 AR DOK3 EGFR FHL3 TRIT1
Entrez ID		54802	126669
HPRD ID		18226	17293
Ensembl ID		ENSG00000043514	ENSG00000169291
Uniprot IDs		Q3T7C7 Q53F11 Q9H3H1	Q5VZ18
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nitric-oxide Synthase Regulator Activity Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process TOR Signaling Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Insulin-like Growth Factor Stimulus Cytoplasmic Translation Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Protein Localization To Cell Periphery Potassium Channel Activator Activity Regulation Of Protein Ubiquitination Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Response To UV Negative Regulation Of Translational Initiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Phosphatidylinositol-3,4,5-trisphosphate Binding Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Regulation Of Glucose Metabolic Process Response To Hormone Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Proteolysis Negative Regulation Of Translation TRNA (guanine-N7)-methylation Response To Ketone Activation-induced Cell Death Of T Cells Positive Regulation Of Translational Initiation Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Regulation Of Protein Localization To Membrane Response To Insulin Cellular Response To Rapamycin Positive Regulation Of Translation Peripheral Nervous System Myelin Maintenance	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Morphogenesis Of An Epithelial Fold Enzyme-linked Receptor Protein Signaling Pathway MAPK Cascade Positive Regulation Of Morphogenesis Of An Epithelium Intracellular Signaling Cassette Positive Regulation Of Fibroblast Proliferation ERBB Signaling Pathway Regulation Of Morphogenesis Of A Branching Structure Enzyme Binding Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Localization To Cytoplasmic Microtubule Plus-end Regulation Of Morphogenesis Of An Epithelium Cellular Response To Lipid ATPase Binding Prostate Induction Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Male Somatic Sex Determination Multivesicular Body, Internal Vesicle Lumen TRNA Dimethylallyltransferase Activity Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Transitional One Stage B Cell Differentiation Animal Organ Development Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Regulation Of Protein Localization To Plasma Membrane Shc-EGFR Complex Regulation Of Growth Positive Regulation Of Mitotic Cell Cycle Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Positive Regulation Of Wnt Signaling Pathway Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Microspike Assembly B-1 B Cell Homeostasis Positive Regulation Of Establishment Of T Cell Polarity Cell Population Proliferation Neuropilin Signaling Pathway
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