MED18 and AFMID

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED18	AFMID
Description		mediator complex subunit 18	arylformamidase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Protein Binding	Arylformamidase Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine 'de Novo' NAD+ Biosynthetic Process From L-tryptophan
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	Tryptophan catabolism
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Vitiligo ( 27723757)
Interacting Genes		9 interacting genes: AFMID CAMK2B HOMEZ MED20 MED31 MED9 TEPSIN TRIM39 USP49	4 interacting genes: CFTR DDIT4L MED18 MEI4
Entrez ID		54797	125061
HPRD ID		17476	16478
Ensembl ID		ENSG00000130772	ENSG00000183077
Uniprot IDs		Q9BUE0	Q63HM1
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Protein-DNA Complex Assembly Arylformamidase Activity Coated Vesicle Membrane Histone H2B Deubiquitinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex L-tryptophan Catabolic Process To Kynurenine	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Meiotic DNA Double-strand Break Formation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Lateral Element Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation
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