PPP1R12C and FMR1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		PPP1R12C	FMR1
Description		protein phosphatase 1 regulatory subunit 12C	fragile X messenger ribonucleoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Axon Dendrite Growth Cone Filopodium Tip SMN Complex Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Perikaryon Intracellular Membraneless Organelle Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Growth Cone Filopodium Ribonucleoprotein Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding	G-quadruplex RNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding SiRNA Binding MiRNA Binding Signaling Adaptor Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Histone H3 Reader Activity Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity Sequence-specific MRNA Binding
	Biological Process	Signal Transduction Neuron Projection Morphogenesis	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor Internalization DNA Repair Chromatin Organization MRNA Processing MRNA Export From Nucleus Regulation Of Translation DNA Damage Response Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Regulation Of Cell Communication Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Stress Granule Assembly Regulation Of MRNA Stability Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Regulation Of Biological Quality Cellular Response To Virus Regulation Of Neuronal Action Potential Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Cytoplasmic Translation
Pathways
Drugs
Diseases			Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)
Interacting Genes		27 interacting genes: AIRIM ATP6V1H ATXN7 BHLHA9 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1	50 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 H19 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 SRC STAU1 SUOX TACC2 UBE2I USP7 WEE2-AS1 YBX1 ZBTB42 ZFPM2 ZMYND8
Entrez ID		54776	2332
HPRD ID		11452	02398
Ensembl ID		ENSG00000125503	ENSG00000102081
Uniprot IDs		Q9BZL4	Q06787
PDB IDs			2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Translation Regulator Activity RNA Transport Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Nucleobase-containing Compound Transport RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Positive Regulation Of MiRNA-mediated Gene Silencing Transcription Export Complex Cytosol Protein Heterodimerization Activity Positive Regulation Of Interleukin-1 Production RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Nucleolus MRNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1 Production Positive Regulation Of Positive Chemotaxis Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Nuclear Export MRNA 3'-UTR Binding Negative Regulation Of Microtubule Depolymerization Protein Binding Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Muscle Cell Fate Specification Myosin-light-chain-phosphatase Activity Regulation Of Microtubule Depolymerization Neural Crest Cell Delamination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Catabolic Process Cytoplasm Neuron Projection Nucleic Acid Binding RNA Binding Positive Regulation Of Translation	Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Negative Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule Synapse Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Metabolic Process Neuron Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Cytoplasmic Ribonucleoprotein Granule Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Cytoskeleton Positive Regulation Of Long-term Neuronal Synaptic Plasticity GMP Kinase Activity Regulation Of Synaptic Plasticity Regulation Of Circadian Rhythm Regulation Of Macromolecule Metabolic Process Dendrite Extension Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Primary Metabolic Process GDP Metabolic Process SCAR Complex Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Deacetylation Microtubule-based Process Regulation Of Signal Transduction Postsynapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Metabolic Process RNA Splicing Positive Regulation Of Organelle Organization Transferase Complex RNA 7-methylguanosine Cap Binding Positive Regulation Of Cellular Component Biogenesis Nuclear Body Nucleoplasm MRNA Binding
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